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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2008-6-18
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pubmed:abstractText |
Oral submucous fibrosis (OSF) is a precancerous condition showing extensive fibrosis of the submucosa and affects most parts of the oral cavity, including pharynx and upper third of the oesophagus. The molecules involved in the biological pathways of the fibrotic process appeared to be either down- or upregulated at different stages of the disease. Despite the precancerous nature, malignant transformation of the epithelium in the background of fibrosis has not been studied in detail. HIF-1alpha is a known transcription factor that is induced by hypoxia.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
D
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1600-0714
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pubmed:author |
pubmed-author:AriyawardanaAA,
pubmed-author:CruchleyAA,
pubmed-author:FortuneFF,
pubmed-author:Hagi-PavliEE,
pubmed-author:IqbalZZ,
pubmed-author:LalliAA,
pubmed-author:ParkinsonE KEK,
pubmed-author:PitiyageGG,
pubmed-author:StewartJ EJE,
pubmed-author:TanM JMJ,
pubmed-author:TilakaratneW MWM,
pubmed-author:WaseemAA
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pubmed:issnType |
Electronic
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
372-7
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pubmed:meshHeading |
pubmed-meshheading:18221327-Cell Transformation, Neoplastic,
pubmed-meshheading:18221327-Epithelial Cells,
pubmed-meshheading:18221327-Fibroblasts,
pubmed-meshheading:18221327-Humans,
pubmed-meshheading:18221327-Hypoxia-Inducible Factor 1, alpha Subunit,
pubmed-meshheading:18221327-Immunohistochemistry,
pubmed-meshheading:18221327-Mouth Neoplasms,
pubmed-meshheading:18221327-Oral Submucous Fibrosis,
pubmed-meshheading:18221327-Retrospective Studies,
pubmed-meshheading:18221327-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:18221327-Tumor Markers, Biological,
pubmed-meshheading:18221327-Up-Regulation
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pubmed:year |
2008
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pubmed:articleTitle |
Upregulation of HIF-1alpha in malignant transformation of oral submucous fibrosis.
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pubmed:affiliation |
Clinical and Diagnostic Oral Sciences, Queen Mary's School of Medicine and Dentistry, University of London, London, UK. wmtilak@pdn.ac.lk
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pubmed:publicationType |
Journal Article
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