Linked Life Data

18219896

Source:http://linkedlifedata.com/resource/pubmed/id/18219896

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2008-1-28
pubmed:abstractText
An 80-year-old female visited our hospital with a chief complaint of anal pain and bleeding. The patient was diagnosed by colonoscopy to have rectal cancer which invaded the perineal region. A pelvic CT also revealed metastases to the lymph node located in the femoral artery. Miles operation was performed and a curative resection was successfully achieved. The pathological findings were poorly differentiated adenocarcinoma with pMP and pN2. Adjuvant chemotherapy was refused by the patient. Paraaortic lymph node metastasis was diagnosed by abdominal CT 6 months after the surgery. The patient was treated with S-1 combined with CPT-11. The S-1 (80 mg/m2) was orally administered for 2 weeks followed by a 2-week interval and CPT-11 (100 mg/m2) was also simultaneously administered biweekly. One cycle of chemotherapy was 28 days. The patient experienced grade 2 leukocytopenia, neutropenia, diarrhea and grade 1 alopecia. Abdominal CT revealed a partial response after 2 cycles. After 10 cycles, the patient continued to demonstrate a partial response. The S-1 combined with CPT-11 regimen for elderly patients was thus found to be very feasible and convenient, and we obtained a good compliance. As a result, this regimen was thus found to be promising for unresectable or recurrent colorectal cancer in elder patients. In the future, the efficacy and safety of this regimen should be verified in phase II clinical trial for elderly patients.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0385-0684
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2053-5
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
[An elderly patient with recurrent rectal cancer successfully responded to S-1 combined with CPT-11].
pubmed:affiliation
Dept. of Surgery, Saiseikai Yokohamashi Tobu Hospital.
pubmed:publicationType
Journal Article, English Abstract, Case Reports