Linked Life Data

18219131

Source:http://linkedlifedata.com/resource/pubmed/id/18219131

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-1-25
pubmed:abstractText
Traditional risk factors are not adequate for predicting serious bacterial infection (SBI) in febrile infants. The purpose of this study was to evaluate the diagnostic value of the plasma level of soluble form of triggering receptor expressed on myeloid cells-1 (sTREM-1) in predicting SBI in febrile infants less than 3 months old. Forty-four febrile infants less than 3 months old with clinical suspicion of SBI were enrolled. Blood was drawn for measurement of plasma sTREM-1 levels, and microbiological cultures were obtained at the time of admission. Twenty-three infants (52.3%) had SBI and 21 infants (47.7%) had no evidence of SBI based on the results of bacterial culture. sTREM-1 levels were significantly higher in infants with SBI than in infants without SBI (mean+/-SD, 324.6+/-546.3 versus 7.7+/-16.4, P<0.0001 after adjusting for age). The area under the receiver-operating characteristic curve was 0.88 for the sTREM-1 level. At a cutoff level of 24.4 ng/mL, the sTREM-1 level yielded a sensitivity of 87%, a specificity of 81%, a positive likelihood ratio of 4.6, and a negative likelihood ratio of 0.2 for differentiating between presence and absence of SBI. In conclusion, sTREM-1 may become a valuable diagnostic tool in the initial evaluation of febrile young infants.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1344-6304
pubmed:author
pubmed:issnType
Print
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
31-5
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Soluble form of triggering receptor expressed on myeloid cells-1 (sTREM-1) as a diagnostic marker of serious bacterial infection in febrile infants less than three months of age.
pubmed:affiliation
Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Evaluation Studies