Linked Life Data

18219095

Source:http://linkedlifedata.com/resource/pubmed/id/18219095

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pubmed-article:18219095pubmed:abstractTextGene expression of Dickkopf-3 (Dkk-3) has been shown to be upregulated in tumor endothelium of colorectal cancer (CRC). For the first time, we analyzed Dkk-3 protein expression in CRC and its potential as a marker for neoangiogenesis. We used tissue microarrays (TMAs) to investigate Dkk-3 in microvessels of 403 CRC samples, 318 appropriate adjacent non-cancerous samples and 127 normal colorectal samples. Of cancer samples with CD31-positive microvessels, 67.7% were positive for Dkk-3. Dkk-3 staining was demonstrated in endothelial cells of all microvessels in nearly all cases. Dkk-3-positive samples showed a higher mean microvessel count than did Dkk-3-negative samples (P=0.001). Dkk-3 expression increased with rising numbers of microvessels per sample (P<0.0001). In adjacent samples with CD31-positive microvessels, 56% were Dkk-3-positive in all microvessels. Similar to cancer samples, Dkk-3-positive adjacent samples had a higher mean microvessel count than did Dkk-3-negative samples (P<0.0001), and Dkk-3 expression also increased with rising numbers of microvessels (P<0.0001). All microvessels in normal mucosa samples were negative for Dkk-3. Dkk-3 can be considered a putative pro-angiogenic protein in neovascularization and may possibly be a marker for neoangiogenesis in CRC. Further investigations will elucidate whether Dkk-3 is a target structure for novel therapies.lld:pubmed
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pubmed-article:18219095pubmed:year2008lld:pubmed
pubmed-article:18219095pubmed:articleTitleDickkopf-3 as a new potential marker for neoangiogenesis in colorectal cancer: expression in cancer tissue and adjacent non-cancerous tissue.lld:pubmed
pubmed-article:18219095pubmed:affiliationDepartment of General and Transplant Surgery, Innsbruck Medical University, Innsbruck, Austria. matthias.zitt@i-med.ac.atlld:pubmed
pubmed-article:18219095pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:18219095pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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