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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2008-4-9
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pubmed:abstractText |
Retinoic acid (RA) is a major chemopreventive agent which exerts strong anti-tumor activity partly by trans-repressing the Wnt/beta-catenin signaling pathway in some tumor cell lines. However, the definite mechanism of RA trans-repression of the Wnt/beta-catenin signaling pathway has not been elucidated clearly. In this work, we found that all-trans retinoic acid (ATRA) significantly inhibited proliferation of glioma cells, accompanied by up-regulation of expression of Axin and altered subcellular distribution of beta-catenin. Transfecting C6 cells with rAxin further confirmed that increased expression of Axin is obligate for inhibition of proliferation and the increase of the cytoplasmic beta-catenin. Our results suggested that Axin might play an important role in RA-mediated anti-proliferative effects of glioma cell lines.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0167-594X
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pubmed:author |
pubmed-author:HongLiuL,
pubmed-author:LeeM KMK,
pubmed-author:LiFanfanF,
pubmed-author:LiHangH,
pubmed-author:LiuN BNB,
pubmed-author:LuJianrongJ,
pubmed-author:StamJ WJW,
pubmed-author:XXX,
pubmed-author:ZhangFengF,
pubmed-author:ZhangLiyingL,
pubmed-author:ZhaoDaqingD
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pubmed:issnType |
Print
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pubmed:volume |
87
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
271-7
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18217212-Animals,
pubmed-meshheading:18217212-Antineoplastic Agents,
pubmed-meshheading:18217212-Axin Protein,
pubmed-meshheading:18217212-Blotting, Western,
pubmed-meshheading:18217212-Brain Neoplasms,
pubmed-meshheading:18217212-Cell Proliferation,
pubmed-meshheading:18217212-Fluorescent Antibody Technique,
pubmed-meshheading:18217212-Glioma,
pubmed-meshheading:18217212-Humans,
pubmed-meshheading:18217212-Protein Transport,
pubmed-meshheading:18217212-Rats,
pubmed-meshheading:18217212-Repressor Proteins,
pubmed-meshheading:18217212-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:18217212-Transfection,
pubmed-meshheading:18217212-Tretinoin,
pubmed-meshheading:18217212-Up-Regulation,
pubmed-meshheading:18217212-beta Catenin
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pubmed:year |
2008
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pubmed:articleTitle |
ATRA-inhibited proliferation in glioma cells is associated with subcellular redistribution of beta-catenin via up-regulation of Axin.
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pubmed:affiliation |
Department of Pathology, State Key Laboratory of Cancer Biology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province 710032, PR China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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