Source:http://linkedlifedata.com/resource/pubmed/id/18217135
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2008-1-24
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| pubmed:abstractText |
Moderate alcohol consumption is associated with lower levels of several coagulation factors. It is an established protective factor for cardiovascular disease; however, the effect on venous thrombosis is unknown. In a large population-based case-control study, we evaluated the association between alcohol consumption and the risk of venous thrombosis. The MEGA study included consecutive patients with a first venous thrombosis between March 1999 and September 2004 from six anticoagulation clinics in the Netherlands. Partners of patients were asked to participate, and additional controls were recruited using a random digit dialling method. All participants completed a standardized questionnaire, and blood samples were collected. A total of 4,423 patients and 5,235 controls were included in the analyses. Alcohol consumption was associated with a reduced risk of venous thrombosis, with 2-4 glasses per day resulting in the largest beneficial effect (odds ratio [OR] 0.67, 95% confidence interval [CI95] 0.58-0.77) compared to abstainers. The effect was more pronounced in women (OR 0.66, CI95 0.53-0.84) than men (OR 0.82, CI95 0.63-1.07) and also more striking for pulmonary embolism (OR 0.56, CI95 0.46-0.70) than for deep venous thrombosis of the leg (OR 0.74, CI95 0.63-0.88). Compared to abstainers, fibrinogen levels were decreased in individuals who consumed alcohol (maximum decrease: 0.30 g/l). Factor VII and von Willebrand levels were mildly decreased in these individuals but not consistently over the categories of alcohol consumption. In conclusion, alcohol consumption is associated with a reduced risk of venous thrombosis, which may be in part mediated by decreased fibrinogen levels.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
0340-6245
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
99
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
59-63
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| pubmed:meshHeading |
pubmed-meshheading:18217135-Adult,
pubmed-meshheading:18217135-Aged,
pubmed-meshheading:18217135-Alcohol Drinking,
pubmed-meshheading:18217135-Case-Control Studies,
pubmed-meshheading:18217135-Down-Regulation,
pubmed-meshheading:18217135-Factor VII,
pubmed-meshheading:18217135-Female,
pubmed-meshheading:18217135-Fibrinogen,
pubmed-meshheading:18217135-Humans,
pubmed-meshheading:18217135-Male,
pubmed-meshheading:18217135-Middle Aged,
pubmed-meshheading:18217135-Netherlands,
pubmed-meshheading:18217135-Odds Ratio,
pubmed-meshheading:18217135-Pulmonary Embolism,
pubmed-meshheading:18217135-Questionnaires,
pubmed-meshheading:18217135-Risk Assessment,
pubmed-meshheading:18217135-Risk Factors,
pubmed-meshheading:18217135-Sex Factors,
pubmed-meshheading:18217135-Venous Thrombosis,
pubmed-meshheading:18217135-von Willebrand Factor
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| pubmed:year |
2008
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| pubmed:articleTitle |
Alcohol consumption is associated with a decreased risk of venous thrombosis.
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| pubmed:affiliation |
Department of Clinical Epidemiology, C9-P, Leiden University Medical Center, Leiden, The Netherlands.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study
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