Linked Life Data

1821703

Source:http://linkedlifedata.com/resource/pubmed/id/1821703

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1992-8-26
pubmed:abstractText
Twenty-six healthy volunteers received either 25 micrograms of cholecystokinin-tetrapeptide (CCK-4) or a mixture of 35% carbon dioxide in oxygen (CO2). DSM-III-R criteria including anxiety, apprehension and/or fear of at least moderate intensity were used to determine the occurrence of a panic attack. Results for the entire sample revealed that CCK-4 produced significantly more intense symptoms than CO2, but not a significantly greater number of symptoms. The incidence of DSM-III-R panic attacks was similar with both substances; 21% (3/14) for CO2 and 17% (2/12) for CCK-4. This study indicates that CCK-4 is at least as potent as CO2 in producing panic symptoms in healthy volunteers and is a useful challenge paradigm for comparative research of pharmacologic agents which possess distinct neurobiologic properties.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0924-977X
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
137-41
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Comparison of the effects of cholecystokinin-tetrapeptide and carbon dioxide in health volunteers.
pubmed:affiliation
Department of Psychiatry, St. Mary's Hospital Centre, McGill University, Montreal, Quebec, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't