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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2008-3-5
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pubmed:abstractText |
Basal C-reactive protein (CRP) is a heritable trait associated with long-term cardiovascular disease risk. Existing studies leave ambiguity over the key functional polymorphisms and fail to adjust for trans-acting effects. In a novel cohort of 285 Filipino systemic lupus erythematosus probands and their first-degree relatives, we quantified serum CRP and typed a dense map of CRP single-nucleotide polymorphisms (SNPs), along with SNPs in the interleukin-1 beta, interleukin-6 and apolipoprotein E genes. Ten CRP SNPs demonstrated association with basal CRP in a regression model (P=0.011-0.002). These delineated two haplotypes associated with high and low basal CRP expression (P=0.002). Differences in allele frequency were seen compared with Caucasian populations, enabling us to argue for an independent genetic effect from a phylogenetically distinct haplotype tagged by SNP rs1800947. We demonstrated an association between Apo epsilon 2 and higher basal CRP. Interleukin-6 genotype was associated with basal CRP, highlighting a role for acute-phase cytokines even in basal expression. Identifying these trans-acting variants may improve the use of basal CRP as a predictor cardiovascular risk, and increase our power to detect associations between CRP and disease.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18216863-10408362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18216863-11050560,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/18216863-7387742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18216863-8412653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18216863-9634505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18216863-9853617
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1476-5470
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
153-60
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:18216863-Adult,
pubmed-meshheading:18216863-Amino Acid Sequence,
pubmed-meshheading:18216863-Asian Continental Ancestry Group,
pubmed-meshheading:18216863-C-Reactive Protein,
pubmed-meshheading:18216863-Cardiovascular Diseases,
pubmed-meshheading:18216863-Cohort Studies,
pubmed-meshheading:18216863-Female,
pubmed-meshheading:18216863-Gene Expression Regulation,
pubmed-meshheading:18216863-Genetic Linkage,
pubmed-meshheading:18216863-Haplotypes,
pubmed-meshheading:18216863-Humans,
pubmed-meshheading:18216863-Lupus Erythematosus, Systemic,
pubmed-meshheading:18216863-Male,
pubmed-meshheading:18216863-Molecular Sequence Data,
pubmed-meshheading:18216863-Pedigree,
pubmed-meshheading:18216863-Philippines,
pubmed-meshheading:18216863-Risk Factors
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pubmed:year |
2008
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pubmed:articleTitle |
Genetic determinants of basal C-reactive protein expression in Filipino systemic lupus erythematosus families.
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pubmed:affiliation |
Department of Rheumatology, Molecular Genetics and Rheumatology Section, Imperial College London, London, UK.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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