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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2008-3-12
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pubmed:abstractText |
Degradation of de novo-generated adeno-associated virus type 5 (AAV5) Rep52 and capsid proteins is part of the limited target specificity displayed by adenovirus type 5 E4Orf6-E1B-55k as part of a cullin 5-containing E3 ligase complex. Both Rep and capsid proteins can be found in the ligase complex, and their presence is dependent on interaction between E4Orf6 and elongins B and C. Degradation of AAV5 proteins can be inhibited by a dominant-negative ubiquitin that prevents chain elongation or by small interfering RNA directed against cullin 5.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18216112-10882081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18216112-11134283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18216112-11356976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18216112-11437668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18216112-11731475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18216112-12124628,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18216112-12186903,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18216112-15485928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18216112-16926042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18216112-17079297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18216112-17166904,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18216112-17459921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18216112-17898048,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18216112-8627803,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18216112-8794242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18216112-9094654
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1098-5514
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
82
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3803-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
2008
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pubmed:articleTitle |
E4Orf6-E1B-55k-dependent degradation of de novo-generated adeno-associated virus type 5 Rep52 and capsid proteins employs a cullin 5-containing E3 ligase complex.
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pubmed:affiliation |
Department of Molecular Microbiology and Immunology, University of Missouri-Columbia, School of Medicine, Life Sciences Center, Columbia, Missouri 65211, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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