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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2008-1-24
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pubmed:abstractText |
Phagocytes generate nitric oxide (NO) and other reactive oxygen and nitrogen species in large quantities to combat infecting bacteria. Here, we report the surprising observation that in vivo survival of a notorious pathogen-Bacillus anthracis-critically depends on its own NO-synthase (bNOS) activity. Anthrax spores (Sterne strain) deficient in bNOS lose their virulence in an A/J mouse model of systemic infection and exhibit severely compromised survival when germinating within macrophages. The mechanism underlying bNOS-dependent resistance to macrophage killing relies on NO-mediated activation of bacterial catalase and suppression of the damaging Fenton reaction. Our results demonstrate that pathogenic bacteria use their own NO as a key defense against the immune oxidative burst, thereby establishing bNOS as an essential virulence factor. Thus, bNOS represents an attractive antimicrobial target for treatment of anthrax and other infectious diseases.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18215992-10794591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18215992-10922044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18215992-11504674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18215992-11544370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18215992-11872732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18215992-12080063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18215992-12117950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18215992-12220171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18215992-12562816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18215992-12618458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18215992-14527285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18215992-14718666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18215992-14976216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18215992-15378046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18215992-15837388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18215992-16172391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18215992-16239551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18215992-16552057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18215992-16732295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18215992-16890439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18215992-16923876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18215992-17076510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18215992-17084900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18215992-17313521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18215992-17470545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18215992-2584227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18215992-3081444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18215992-7539113,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18215992-7667267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18215992-8234347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18215992-8797819,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18215992-9143691
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1091-6490
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
22
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pubmed:volume |
105
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1009-13
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pubmed:dateRevised |
2011-6-14
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pubmed:meshHeading |
pubmed-meshheading:18215992-Animals,
pubmed-meshheading:18215992-Anthrax,
pubmed-meshheading:18215992-Bacillus anthracis,
pubmed-meshheading:18215992-Cell Line,
pubmed-meshheading:18215992-Cell Survival,
pubmed-meshheading:18215992-Macrophages,
pubmed-meshheading:18215992-Mice,
pubmed-meshheading:18215992-Nitric Oxide,
pubmed-meshheading:18215992-Oxidative Stress,
pubmed-meshheading:18215992-Survival Rate,
pubmed-meshheading:18215992-Time Factors,
pubmed-meshheading:18215992-Virulence
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pubmed:year |
2008
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pubmed:articleTitle |
Bacillus anthracis-derived nitric oxide is essential for pathogen virulence and survival in macrophages.
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pubmed:affiliation |
Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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