Linked Life Data

1821173

Source:http://linkedlifedata.com/resource/pubmed/id/1821173

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1992-8-19
pubmed:abstractText
Neonatal rabbits were exposed to either normoxia (21% oxygen) or hyperoxia (. 95% oxygen) for 2-4 days, and isolated ventilated perfused lung preparations from the various animals were studied. 5-Hydroxytryptamine (5HT) uptake, perfusion pressure, alveolar lavage protein and lung tissue vitamin E concentrations were measured. There was no difference in mortality between the two groups at any time point. There was no difference in perfusion pressures at any time point. There were no differences between normoxic and hyperoxic animals in alveolar lavage protein or 5 HT uptake at 2 and 3 days. At 4 days, 5HT uptake (fractional) was lower in the hyperoxia group than in controls (0.65 +/- 0.033 v. 0.75 +/- 0.013 (mean +/- SE); p less than or equal to 0.05) and alveolar lavage protein was higher compared to normoxia (1111 +/- 415 micrograms/ml v. 481 +/- 78 micrograms/ml; p less than or equal to 0.05). Lung vitamin E concentrations were higher at 3 days in rabbits exposed to hyperoxia compared to normoxia (16.5 +/- 1.8 micrograms/gm v. 12.3 +/- 0.6 micrograms/gm; p less than or equal to 0.05). In air exposed animals there was a decrease in lung vitamin E concentration after 2 days, whereas hyperoxia exposed animals had no significant decrease in lung vitamin E concentrations from 2-4 days exposure. These studies establish that the decrease in 5HT uptake, albeit delayed compared to that described previously in adult animals, is a reasonable measure of pulmonary oxygen toxicity in newborn rabbits.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0952-0600
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
151-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Effect of hyperoxia on 5-hydroxytryptamine uptake by the neonatal rabbit lung.
pubmed:affiliation
Department of Pediatrics, College of Medicine, University of Florida, Gainesville 32610.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't