Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:18211505rdf:typepubmed:Citationlld:pubmed
pubmed-article:18211505lifeskim:mentionsumls-concept:C0086418lld:lifeskim
pubmed-article:18211505lifeskim:mentionsumls-concept:C0039005lld:lifeskim
pubmed-article:18211505lifeskim:mentionsumls-concept:C1135183lld:lifeskim
pubmed-article:18211505lifeskim:mentionsumls-concept:C1332717lld:lifeskim
pubmed-article:18211505lifeskim:mentionsumls-concept:C1706438lld:lifeskim
pubmed-article:18211505lifeskim:mentionsumls-concept:C0225336lld:lifeskim
pubmed-article:18211505lifeskim:mentionsumls-concept:C0085358lld:lifeskim
pubmed-article:18211505lifeskim:mentionsumls-concept:C0017262lld:lifeskim
pubmed-article:18211505lifeskim:mentionsumls-concept:C1413244lld:lifeskim
pubmed-article:18211505lifeskim:mentionsumls-concept:C2698600lld:lifeskim
pubmed-article:18211505lifeskim:mentionsumls-concept:C1413357lld:lifeskim
pubmed-article:18211505lifeskim:mentionsumls-concept:C1533691lld:lifeskim
pubmed-article:18211505lifeskim:mentionsumls-concept:C1708528lld:lifeskim
pubmed-article:18211505lifeskim:mentionsumls-concept:C1515655lld:lifeskim
pubmed-article:18211505lifeskim:mentionsumls-concept:C2911684lld:lifeskim
pubmed-article:18211505lifeskim:mentionsumls-concept:C0185117lld:lifeskim
pubmed-article:18211505pubmed:issue2lld:pubmed
pubmed-article:18211505pubmed:dateCreated2008-1-23lld:pubmed
pubmed-article:18211505pubmed:abstractTextOvercoming cell-mediated immunity, especially of human CD8(+) CTLs, is important for the success of xenotransplantation. Our group has previously reported that the cytotoxicity of human CD8(+) CTLs against pig endothelial cells (PEC) is highly detrimental and mediated in major part by the Fas/FasL apoptotic pathway. Cellular FLICE inhibitory protein (c-FLIP) was originally identified as an inhibitor of death-receptor signaling through binding competition with caspase-8 for recruitment to Fas-associated via death domain (FADD). Two major c-FLIP variants result from alternative mRNA splicing: a short, 26-KDa protein (c-FLIP(S)) and a long, 55-KDa form (c-FLIP(L)). The cytoprotective effects of c-FLIP(S/L) in xenograft cells remain controversial. This study demonstrates that the overexpression of c-FLIP(S/L) genes markedly suppress human CD8(+) CTL-mediated xenocytotoxicity and, in addition, the cytoprotective effects of c-FLIP(L) appear to be significantly stronger than those of c-FLIP(S). Furthermore, to prove the prolonged effects of xenograft survival, PEC transfectants with c-FLIP(S/L) genes were transplanted under rat kidney capsules. Prolonged survival was elicited from FLIP(S/L) transfectants, whereas parental PEC was completely rejected through day 5, posttransplant. Thus, intracellular remodeling with the overexpression of c-FLIP(S/L) in xenograft cells may avoid innate cellular attacks against xenografts and facilitate long-term xenograft survival.lld:pubmed
pubmed-article:18211505pubmed:languageenglld:pubmed
pubmed-article:18211505pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18211505pubmed:citationSubsetIMlld:pubmed
pubmed-article:18211505pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18211505pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18211505pubmed:statusMEDLINElld:pubmed
pubmed-article:18211505pubmed:monthFeblld:pubmed
pubmed-article:18211505pubmed:issn1600-6143lld:pubmed
pubmed-article:18211505pubmed:authorpubmed-author:ItoTTlld:pubmed
pubmed-article:18211505pubmed:authorpubmed-author:DeguchiTTlld:pubmed
pubmed-article:18211505pubmed:authorpubmed-author:TanemuraMMlld:pubmed
pubmed-article:18211505pubmed:authorpubmed-author:MachidaTTlld:pubmed
pubmed-article:18211505pubmed:authorpubmed-author:SavuLLlld:pubmed
pubmed-article:18211505pubmed:authorpubmed-author:NishidaTTlld:pubmed
pubmed-article:18211505pubmed:authorpubmed-author:SagiYYlld:pubmed
pubmed-article:18211505pubmed:authorpubmed-author:KawamotoKKlld:pubmed
pubmed-article:18211505pubmed:issnTypeElectroniclld:pubmed
pubmed-article:18211505pubmed:volume8lld:pubmed
pubmed-article:18211505pubmed:ownerNLMlld:pubmed
pubmed-article:18211505pubmed:authorsCompleteYlld:pubmed
pubmed-article:18211505pubmed:pagination288-97lld:pubmed
pubmed-article:18211505pubmed:meshHeadingpubmed-meshheading:18211505...lld:pubmed
pubmed-article:18211505pubmed:meshHeadingpubmed-meshheading:18211505...lld:pubmed
pubmed-article:18211505pubmed:meshHeadingpubmed-meshheading:18211505...lld:pubmed
pubmed-article:18211505pubmed:meshHeadingpubmed-meshheading:18211505...lld:pubmed
pubmed-article:18211505pubmed:meshHeadingpubmed-meshheading:18211505...lld:pubmed
pubmed-article:18211505pubmed:meshHeadingpubmed-meshheading:18211505...lld:pubmed
pubmed-article:18211505pubmed:meshHeadingpubmed-meshheading:18211505...lld:pubmed
pubmed-article:18211505pubmed:meshHeadingpubmed-meshheading:18211505...lld:pubmed
pubmed-article:18211505pubmed:meshHeadingpubmed-meshheading:18211505...lld:pubmed
pubmed-article:18211505pubmed:meshHeadingpubmed-meshheading:18211505...lld:pubmed
pubmed-article:18211505pubmed:meshHeadingpubmed-meshheading:18211505...lld:pubmed
pubmed-article:18211505pubmed:meshHeadingpubmed-meshheading:18211505...lld:pubmed
pubmed-article:18211505pubmed:meshHeadingpubmed-meshheading:18211505...lld:pubmed
pubmed-article:18211505pubmed:meshHeadingpubmed-meshheading:18211505...lld:pubmed
pubmed-article:18211505pubmed:year2008lld:pubmed
pubmed-article:18211505pubmed:articleTitleIn vitro and in vivo prevention of human CD8+ CTL-mediated xenocytotoxicity by pig c-FLIP expression in porcine endothelial cells.lld:pubmed
pubmed-article:18211505pubmed:affiliationDepartment of Surgery (E1), Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan. tanemura@surg1.med.osaka-u.ac.jplld:pubmed
pubmed-article:18211505pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:18211505pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
entrez-gene:414381entrezgene:pubmedpubmed-article:18211505lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:18211505lld:entrezgene