Linked Life Data

1820934

Source:http://linkedlifedata.com/resource/pubmed/id/1820934

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1992-8-10
pubmed:abstractText
COR3224, a new 2-amino2 oxazoline derivative, shows antidepressant activity in the rat. This study was designed to analyse the influence of dose ranging on the brain/plasma concentration ratio of this drug. Adult male rats (250-300gr, Sprague Dawley) were given orally 10, 40 and 160 mg/Kg radiolabelled 14C-COR3224 (30 microCi/kg) in aqueous solution and were sacrificed at 0.25; 0.5; 0.75; 1; 2; 4; 6; 8; 12; 16; 24; and 30 hours post dose (5 rats per time). Plasma and brain samples were analysed for total radioactivity (T.R.) by liquid scintillation and for COR3224 (U.P.) by reversed-phase liquid chromatography and electrochemical detection. A linear relationship was found between AUC and doses administered for both TR and UP plasmatic determinations. In opposite, cerebral AUC for TR and U.P were not proportional to dose, and the evolution of the brain/plasma concentration ratios showed higher values for the 10mg/kg dose than for the 40 and 160mg/kg doses.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0378-7966
pubmed:author
pubmed:issnType
Print
pubmed:volume
Spec No 3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
52-6
pubmed:dateRevised
2011-2-2
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Kinetics and brain uptake of COR3224, a new 2-amino-2-oxazoline, in rats.
pubmed:affiliation
Lab. Pharmacologie et de Pharmacocinétique, Fac. de Pharmacie, Chatenay-Malabry, France.
pubmed:publicationType
Journal Article