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rdf:type |
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lifeskim:mentions |
umls-concept:C0013604,
umls-concept:C0026336,
umls-concept:C0035126,
umls-concept:C0038891,
umls-concept:C0185125,
umls-concept:C0205228,
umls-concept:C0225700,
umls-concept:C0920711,
umls-concept:C1280500,
umls-concept:C1522492,
umls-concept:C1882727
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pubmed:dateCreated |
2008-3-7
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pubmed:abstractText |
Prophylactic exogenous surfactant therapy is a promising way to attenuate the ischemia and reperfusion (I/R) injury associated with lung transplantation and thereby to decrease the clinical occurrence of acute lung injury and acute respiratory distress syndrome. However, there is little information on the mode by which exogenous surfactant attenuates I/R injury of the lung. We hypothesized that exogenous surfactant may act by limiting pulmonary edema formation and by enhancing alveolar type II cell and lamellar body preservation. Therefore, we investigated the effect of exogenous surfactant therapy on the formation of pulmonary edema in different lung compartments and on the ultrastructure of the surfactant producing alveolar epithelial type II cells.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18205928-10321996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18205928-10414401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18205928-10430751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18205928-10452345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18205928-10759447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18205928-11360229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18205928-11684833,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18205928-11686863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18205928-11782748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18205928-12517997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18205928-12588712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18205928-12709583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18205928-14762340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18205928-15052656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18205928-15329426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18205928-15764726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18205928-15848313,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18205928-15969762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18205928-16210116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18205928-16394779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18205928-16872418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18205928-16973815,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18205928-17532965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18205928-1797938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18205928-1953154,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18205928-4601625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18205928-5530651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18205928-6737468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18205928-6881707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18205928-7643600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18205928-7778861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18205928-8482664,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18205928-8564115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18205928-8678672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18205928-8680706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18205928-9202686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18205928-9532002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18205928-9731097
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1465-993X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18205928-Animals,
pubmed-meshheading:18205928-Disease Models, Animal,
pubmed-meshheading:18205928-Lung Diseases,
pubmed-meshheading:18205928-Male,
pubmed-meshheading:18205928-Pulmonary Alveoli,
pubmed-meshheading:18205928-Pulmonary Edema,
pubmed-meshheading:18205928-Pulmonary Surfactants,
pubmed-meshheading:18205928-Random Allocation,
pubmed-meshheading:18205928-Rats,
pubmed-meshheading:18205928-Rats, Sprague-Dawley,
pubmed-meshheading:18205928-Reference Values,
pubmed-meshheading:18205928-Reperfusion Injury
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pubmed:year |
2008
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pubmed:articleTitle |
Exogenous surfactant application in a rat lung ischemia reperfusion injury model: effects on edema formation and alveolar type II cells.
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pubmed:affiliation |
Department of Anatomy, Division of Electron Microscopy, University of Göttingen, Kreuzbergring 36, D-37075 Göttingen, Germany. Niels.Dreyer@med.uni-heidelberg.de
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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