Source:http://linkedlifedata.com/resource/pubmed/id/18205890
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
Pt 2
|
| pubmed:dateCreated |
2008-2-13
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| pubmed:abstractText |
CYP2C19, a member of the cytochrome P450 family, metabolises arachidonic acid to produce epoxyeicosanoid acids, which are involved in vascular tone and inflammation. Thus, this study describes the possible relationship between a CYP2C19 polymorphism (681G>A) and three inflammatory markers: interleukin (IL)-6, tumor necrosis factor-alpha (TNF-alpha) and high sensitivity C-reactive protein (hs-CRP) in healthy individuals. In a sub-sample of 178 men and 181 women from the Stanislas study, we quantified plasma IL-6 and TNF-alpha concentrations by using an enzyme-linked immunosorbent assay, and serum hs-CRP concentration by immunonephelometry. The CYP2C19 681G>A polymorphism was genotyped using the kinetic thermocycling allele specific PCR method. In the Stanislas cohort, the frequency of the allele CYP2C19*2 (681A) was 17.8%. Circulating levels of inflammatory factors were increased in individuals homozygous for the defective allele CYP2C19*2 (A) notably IL-6 in the whole sample (P= 0.0008) and hs-CRP only in women (P= 0.008), with a significant interaction with sex (P= 0.005), in comparison to carriers of one copy or more of the wild type allele CYP2C19*1 (G). Only a trend of association (P= 0.089) was found between this polymorphism and TNF-alpha concentration in the whole sample. The association between CYP2C19*2 polymorphism and inflammatory markers' concentrations could suggest that CYP2C19 may be considered as a new candidate gene for cardiovascular risks via inflammation.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aryl Hydrocarbon Hydroxylases,
http://linkedlifedata.com/resource/pubmed/chemical/C-Reactive Protein,
http://linkedlifedata.com/resource/pubmed/chemical/CYP2C19 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Mixed Function Oxygenases,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0003-4800
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
72
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
178-83
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| pubmed:meshHeading |
pubmed-meshheading:18205890-Adult,
pubmed-meshheading:18205890-Analysis of Variance,
pubmed-meshheading:18205890-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:18205890-C-Reactive Protein,
pubmed-meshheading:18205890-Cohort Studies,
pubmed-meshheading:18205890-DNA Primers,
pubmed-meshheading:18205890-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:18205890-European Continental Ancestry Group,
pubmed-meshheading:18205890-Female,
pubmed-meshheading:18205890-France,
pubmed-meshheading:18205890-Gene Frequency,
pubmed-meshheading:18205890-Genotype,
pubmed-meshheading:18205890-Humans,
pubmed-meshheading:18205890-Inflammation,
pubmed-meshheading:18205890-Interleukin-6,
pubmed-meshheading:18205890-Male,
pubmed-meshheading:18205890-Middle Aged,
pubmed-meshheading:18205890-Mixed Function Oxygenases,
pubmed-meshheading:18205890-Nephelometry and Turbidimetry,
pubmed-meshheading:18205890-Polymorphism, Genetic,
pubmed-meshheading:18205890-Tumor Necrosis Factor-alpha
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| pubmed:year |
2008
|
| pubmed:articleTitle |
Genetic Polymorphism of CYP2C19 gene in the Stanislas cohort. A link with inflammation.
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| pubmed:affiliation |
INSERM U525, Faculté de Pharmacie, 30 rue Lionnois, Nancy, France.
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|