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pubmed-article:18205378pubmed:abstractTextA stereoselective and efficient total synthesis of optically active tetrodotoxin (TTX) is described. A polyfunctionalized key cyclitol compound containing branched-chains for the synthesis of TTX was prepared from D-glucose employing the Henry reaction (Nitro aldol reaction) as the key transformation. Stereoselective construction of the alpha-azido-aldehyde branched-chain was achieved via the key spiro alpha-chloroepoxide intermediate.lld:pubmed
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pubmed-article:18205378pubmed:authorpubmed-author:SatoKen-ichiKlld:pubmed
pubmed-article:18205378pubmed:authorpubmed-author:SuzukiKatsuhi...lld:pubmed
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pubmed-article:18205378pubmed:authorpubmed-author:FunabashiMasu...lld:pubmed
pubmed-article:18205378pubmed:authorpubmed-author:YoshidaShihoSlld:pubmed
pubmed-article:18205378pubmed:authorpubmed-author:NagaiYoshinao...lld:pubmed
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pubmed-article:18205378pubmed:articleTitleStereoselective and efficient total synthesis of optically active tetrodotoxin from D-glucose.lld:pubmed
pubmed-article:18205378pubmed:affiliationDepartment of Applied Chemistry, Faculty of Engineering, Kanagawa University, Yokohama, 221-8686, Japan. satouk01@kanagawa-u.ac.jplld:pubmed
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