Source:http://linkedlifedata.com/resource/pubmed/id/18205296
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2008-2-8
|
| pubmed:abstractText |
The use of protein ESI mass spectrometry under non-denaturing conditions to analyze a dynamic combinatorial library of thiols/disulfides with the BcII metallo-beta-lactamase enabled the rapid identification of an inhibitor with a K(i) of < 1 microM. The study exemplifies the utility of protein-MS for screening dynamic mixtures of potential enzyme-inhibitors.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0022-2623
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
14
|
| pubmed:volume |
51
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
684-8
|
| pubmed:meshHeading |
pubmed-meshheading:18205296-Kinetics,
pubmed-meshheading:18205296-Models, Molecular,
pubmed-meshheading:18205296-Spectrometry, Mass, Electrospray Ionization,
pubmed-meshheading:18205296-Structure-Activity Relationship,
pubmed-meshheading:18205296-Sulfhydryl Compounds,
pubmed-meshheading:18205296-beta-Lactamases
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
Dynamic combinatorial mass spectrometry leads to metallo-beta-lactamase inhibitors.
|
| pubmed:affiliation |
Chemistry Research Laboratory and OCISB, Oxford, UK.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|