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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2008-1-29
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pubmed:abstractText |
We identified and replicated an association between ITGAM (CD11b) at 16p11.2 and risk of systemic lupus erythematosus (SLE) in 3,818 individuals of European descent. The strongest association was at a nonsynonymous SNP, rs1143679 (P = 1.7 x 10(-17), odds ratio = 1.78). We further replicated this association in two independent samples of individuals of African descent (P = 0.0002 and 0.003; overall meta-analysis P = 6.9 x 10(-22)). The genetic association between ITGAM and SLE implicates the alpha(M)beta2-integrin adhesion pathway in disease development.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/AI044902,
http://linkedlifedata.com/resource/pubmed/grant/AI053747,
http://linkedlifedata.com/resource/pubmed/grant/AI063622,
http://linkedlifedata.com/resource/pubmed/grant/AI24717,
http://linkedlifedata.com/resource/pubmed/grant/AI31584,
http://linkedlifedata.com/resource/pubmed/grant/AR048928,
http://linkedlifedata.com/resource/pubmed/grant/AR048940,
http://linkedlifedata.com/resource/pubmed/grant/AR049084,
http://linkedlifedata.com/resource/pubmed/grant/AR12253,
http://linkedlifedata.com/resource/pubmed/grant/AR42460,
http://linkedlifedata.com/resource/pubmed/grant/DE15223,
http://linkedlifedata.com/resource/pubmed/grant/HL 34363,
http://linkedlifedata.com/resource/pubmed/grant/RR01577,
http://linkedlifedata.com/resource/pubmed/grant/RR020143,
http://linkedlifedata.com/resource/pubmed/grant/RR14467
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1546-1718
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pubmed:author |
pubmed-author:Alarcón-RiquelmeMarta EME,
pubmed-author:ChenWeiW,
pubmed-author:GilkesonGary SGS,
pubmed-author:GuthridgeJoel MJM,
pubmed-author:HanShizhongS,
pubmed-author:HarleyJohn BJB,
pubmed-author:JamesJudith AJA,
pubmed-author:KaufmanKenneth MKM,
pubmed-author:KellyJennifer AJA,
pubmed-author:Kim-HowardXanaX,
pubmed-author:KimberlyRobert PRP,
pubmed-author:LiQuan-ZhenQZ,
pubmed-author:McEverRodger PRP,
pubmed-author:MerrillJoan TJT,
pubmed-author:NathSwapan KSK,
pubmed-author:ViswanathanParvathiP,
pubmed-author:VyseTimothy JTJ,
pubmed-author:WakelandEdward KEK,
pubmed-author:ZhuChengC
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pubmed:issnType |
Electronic
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
152-4
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:18204448-3' Untranslated Regions,
pubmed-meshheading:18204448-African Americans,
pubmed-meshheading:18204448-Alleles,
pubmed-meshheading:18204448-Antigens, CD11b,
pubmed-meshheading:18204448-Case-Control Studies,
pubmed-meshheading:18204448-Chromosomes, Human, Pair 16,
pubmed-meshheading:18204448-Cohort Studies,
pubmed-meshheading:18204448-Confidence Intervals,
pubmed-meshheading:18204448-European Continental Ancestry Group,
pubmed-meshheading:18204448-Exons,
pubmed-meshheading:18204448-Gene Frequency,
pubmed-meshheading:18204448-Genetic Markers,
pubmed-meshheading:18204448-Genetic Predisposition to Disease,
pubmed-meshheading:18204448-Genetic Variation,
pubmed-meshheading:18204448-Haplotypes,
pubmed-meshheading:18204448-Humans,
pubmed-meshheading:18204448-Lupus Erythematosus, Systemic,
pubmed-meshheading:18204448-Models, Genetic,
pubmed-meshheading:18204448-Odds Ratio,
pubmed-meshheading:18204448-Polymorphism, Single Nucleotide,
pubmed-meshheading:18204448-Probability,
pubmed-meshheading:18204448-Promoter Regions, Genetic,
pubmed-meshheading:18204448-Risk Factors
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pubmed:year |
2008
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pubmed:articleTitle |
A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus.
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pubmed:affiliation |
Genetic Epidemiology Unit, Oklahoma Medical Research Foundation, 825 NE 13th St., Oklahoma City, Oklahoma 73104, USA. Swapan-Nath@omrf.org
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Meta-Analysis,
Research Support, N.I.H., Extramural
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