Linked Life Data

18204325

Source:http://linkedlifedata.com/resource/pubmed/id/18204325

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-1-21
pubmed:abstractText
The remaining pleural dead space after pulmonary resection sometimes causes serious complications, such as empyema. The objective of this study was induction of granulation tissue in uninfected pleural space after pneumonectomy in a rabbit model using implantation of bioabsorbable and porous poly-l-lactic acid and epsilon-caprolactone copolymer (PLAC) cubes. Twelve Japanese white rabbits were randomly split into two groups: the control group (n = 6) underwent simple left pneumonectomy, whereas the experimental group (n = 6) underwent left pneumonectomy followed by filling of the left hemithorax with PLAC cubes. One rabbit in each group was killed at 1, 2, 3, and 6 months after surgery, and pleural tissue was evaluated. In the experimental group, granulation tissue inside the PLAC cubes had begun to form at 1 month after implantation. From 3 months to 6 months, proliferated granulation tissue occupied the left postpneumonectomy pleural space with no residual space. The implanted PLAC material was being gradually degraded. We were able to induce self-assembled granulation tissue in the pleural space after pneumonectomy in a rabbit model using bioabsorbable PLAC cubes. The use of this technique allowed the residual pleural space to be closed after pulmonary resection.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1538-943X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
109-14
pubmed:meshHeading
pubmed:articleTitle
Closure of the pleural dead space after pneumonectomy in a rabbit model: use of bioabsorbable lactic acid and caprolactone copolymer cubes.
pubmed:affiliation
Department of General Thoracic, Breast and Endocrinological Surgery, Faculty of Medicine, Kagawa University, Kagawa, Japan.
pubmed:publicationType
Journal Article