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rdf:type |
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lifeskim:mentions |
umls-concept:C0017337,
umls-concept:C0069717,
umls-concept:C0205179,
umls-concept:C0268138,
umls-concept:C0268141,
umls-concept:C0332293,
umls-concept:C0524550,
umls-concept:C0596581,
umls-concept:C0752046,
umls-concept:C1333232,
umls-concept:C1333355,
umls-concept:C1333356,
umls-concept:C1333359,
umls-concept:C1337030,
umls-concept:C1516213,
umls-concept:C1527249,
umls-concept:C1705470,
umls-concept:C1705972
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pubmed:issue |
5-6
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pubmed:dateCreated |
2008-2-11
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pubmed:abstractText |
Oxaliplatin damages the DNA, leading to apoptosis. XPA, XPD, ERCC1 and XPG genes are involved in DNA repair, and single nucleotide polymorphisms (SNPs) in these genes can influence the efficacy of oxaliplatin. We examined SNPs in these genes and correlated the results with time to progression (TTP), overall survival and response to oxaliplatin in 42 advanced colorectal cancer patients (CRC) treated with first-line oxaliplatin/fluoropyrimidine.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA excision repair protein ERCC-5,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Deoxycytidine,
http://linkedlifedata.com/resource/pubmed/chemical/ERCC1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/ERCC2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Endonucleases,
http://linkedlifedata.com/resource/pubmed/chemical/Fluorouracil,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Organoplatinum Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/XPA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Xeroderma Pigmentosum Group A...,
http://linkedlifedata.com/resource/pubmed/chemical/Xeroderma Pigmentosum Group D...,
http://linkedlifedata.com/resource/pubmed/chemical/capecitabine,
http://linkedlifedata.com/resource/pubmed/chemical/oxaliplatin
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pubmed:status |
MEDLINE
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pubmed:issn |
1423-0232
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pubmed:author |
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pubmed:copyrightInfo |
(c) 2008 S. Karger AG, Basel
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pubmed:issnType |
Electronic
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pubmed:volume |
72
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
364-70
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:18204222-Adult,
pubmed-meshheading:18204222-Aged,
pubmed-meshheading:18204222-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:18204222-Colorectal Neoplasms,
pubmed-meshheading:18204222-DNA Repair,
pubmed-meshheading:18204222-DNA-Binding Proteins,
pubmed-meshheading:18204222-Deoxycytidine,
pubmed-meshheading:18204222-Disease Progression,
pubmed-meshheading:18204222-Endonucleases,
pubmed-meshheading:18204222-Female,
pubmed-meshheading:18204222-Fluorouracil,
pubmed-meshheading:18204222-Humans,
pubmed-meshheading:18204222-Male,
pubmed-meshheading:18204222-Middle Aged,
pubmed-meshheading:18204222-Nuclear Proteins,
pubmed-meshheading:18204222-Organoplatinum Compounds,
pubmed-meshheading:18204222-Polymorphism, Single Nucleotide,
pubmed-meshheading:18204222-Survival Analysis,
pubmed-meshheading:18204222-Transcription Factors,
pubmed-meshheading:18204222-Xeroderma Pigmentosum Group A Protein,
pubmed-meshheading:18204222-Xeroderma Pigmentosum Group D Protein
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pubmed:year |
2007
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pubmed:articleTitle |
Single nucleotide polymorphisms in nucleotide excision repair genes XPA, XPD, XPG and ERCC1 in advanced colorectal cancer patients treated with first-line oxaliplatin/fluoropyrimidine.
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pubmed:affiliation |
Department of Human Anatomy and Embryology, University of Barcelona School of Medicine, Barcelona, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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