Source:http://linkedlifedata.com/resource/pubmed/id/18204198
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
Pt 2
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| pubmed:dateCreated |
2008-1-21
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| pubmed:abstractText |
Pulmonary-renal syndrome (PRS) is defined as a diffuse alveolar hemorrhage and rapidly progressive glomerulonephritis. We present a retrospective study of 22 consecutive patients with Wegener's granulomatosis (WG). Logistic regression analysis and a Wilcoxon test were included in the statistics. Survival time death risk were assessed using the Kaplan-Meier estimator and the Cox proportional hazard model. At recognition, the median Birmingham Vasculitis Activity Score for Wegener's Granulomatosis (BVAS/WG) was 30.0 (23.0-32.5), PO2 on air was 5.8+/-0.5 kPa, creatinine level was 7.2+/-1.4 mg/dl. Fifteen patients were PR3 positive, among them 4 patients were also positive for anti-glomerular basement membrane antibodies (anti-GBM). Renal biopsy was performed in 16 patients. Histological examination reviled segmental necrotizing crescentic GN in 15 patients. Thirteen patients were initially dialysis-dependent, and 7 required ventilatory support. All patients were treated with methylprednisolone and cyclophosphamide (pulses). The patients were followed up for 24+/-8 months. Of the survivors, 55% and 31% were alive after 1 and 2 years. Early recognition and proper treatment may improve outcome in PRS.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenal Cortex Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Antineutrophil...,
http://linkedlifedata.com/resource/pubmed/chemical/Autoantibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Myeloblastin,
http://linkedlifedata.com/resource/pubmed/chemical/Peroxidase
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| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
0867-5910
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
58 Suppl 5
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
839-46
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| pubmed:meshHeading |
pubmed-meshheading:18204198-Adrenal Cortex Hormones,
pubmed-meshheading:18204198-Adult,
pubmed-meshheading:18204198-Aged,
pubmed-meshheading:18204198-Anti-Glomerular Basement Membrane Disease,
pubmed-meshheading:18204198-Antibodies, Antineutrophil Cytoplasmic,
pubmed-meshheading:18204198-Autoantibodies,
pubmed-meshheading:18204198-Female,
pubmed-meshheading:18204198-Humans,
pubmed-meshheading:18204198-Immunosuppressive Agents,
pubmed-meshheading:18204198-Kidney Diseases,
pubmed-meshheading:18204198-Lung Diseases,
pubmed-meshheading:18204198-Male,
pubmed-meshheading:18204198-Middle Aged,
pubmed-meshheading:18204198-Myeloblastin,
pubmed-meshheading:18204198-Peroxidase,
pubmed-meshheading:18204198-Renal Dialysis,
pubmed-meshheading:18204198-Survival Analysis,
pubmed-meshheading:18204198-Wegener Granulomatosis
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| pubmed:year |
2007
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| pubmed:articleTitle |
The role ANCA and anti-GBM antibodies in pulmonary-renal syndrome due to Wegener's granulomatosis.
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| pubmed:affiliation |
Systemic Vasculitis Outpatient Clinic of the Department of Family Medicine, Internal and Metabolic Diseases, Nephrology Unit, Warsaw Medical University, Warsaw, Poland. kzycinska@poczta.fm
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| pubmed:publicationType |
Journal Article
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