Linked Life Data

18203697

Source:http://linkedlifedata.com/resource/pubmed/id/18203697

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2008-6-18
pubmed:abstractText
Recent studies have revealed that the auditory cortex (AC) plays a crucial role in the plastic changes in the physiological properties of subcortical auditory neurons through corticofugal projections. In this study with the C57 mouse, we investigated the receptive field plasticity of the ventral division of the medial geniculate body (MGBv) of the thalamus and the impact of the primary AC using the electrical stimulation of the cholinergic basal forebrain, the nucleus basalies, paired with a tone (tone-ES(NB)). We found that tone-ES(NB) evoked significant changes in MGBv receptive fields; the best frequencies (BFs) of MGBv neurons shifted toward the frequency of the paired tone. The BF shifts of MGBv neurons were maximal when the difference between the BFs of MGBv neurons and the frequency of the paired tone was 7 kHz. In addition to the BF shifts, the minimum threshold was decreased and the spike number was increased in response to the paired tone. Importantly, these plastic changes of MGBv neurons were completely abolished when the AC was inactivated with a cortical application of muscimol, a gamma-aminobutyric acid receptor subtype A receptor agonist. Our data indicate that the corticofugal system is an essential neural substrate for the sound-specific plasticity in the auditory thalamus.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1460-2199
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1521-8
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Corticothalamic feedback for sound-specific plasticity of auditory thalamic neurons elicited by tones paired with basal forebrain stimulation.
pubmed:affiliation
Department of Physiology and Biophysics, Hotchkiss Brain Institute, University of Calgary Faculty of Medicine, Calgary, Alberta T2N 4N1, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't