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pubmed:abstractText |
The purpose of this paper is to observe the blocking effect of topically subepithelial injected drug and Vit A acid painting on chemically induced oral precancerous lesion and to prove, on a certain extent, the hypothesis that subepithelial connective tissue could exert great influence on the differentiation of the epithelium. A total of 49 syrian hamster was used as experimental animal. Both buccal pouches of all animals were painted thrice weekly with 0.5% DMBA in acetone for 6 weeks. Then, they were divided into two groups: Control group and Experimental group. In the latter group, 70.8% precancerous lesions turned into normal epithelial tissue, whereas those untreated animals developed carcinoma by 62%.
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