Linked Life Data

1820201

Source:http://linkedlifedata.com/resource/pubmed/id/1820201

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1992-8-3
pubmed:abstractText
The lipophosphoglycan (LPG) of the intracellular amastigote form of the protozoan parasite Leishmania major is chemically distinct from the LPG on the surface of the extracellular promastigote form. Amastigote LPG is composed of the monosaccharides galactose, glucose, mannose, glucosamine and inositol in the molar ratio 51:30:24:1:1; arabinose is absent. The lipid anchor comprises four alkylglycerols, with alkyl chain lengths 24:0, 22:0, 20:0 and 26:0 in the molar ratio 68:18:8:6. Phosphate is present at 4% w/w of total carbohydrate. HPLC gel permeation reveals LPG to be a polydisperse family of molecules Mr 100-6 kDa. The results from immunological studies with LPG-directed antibodies are consistent with amastigote LPG having the expected tripartite structure of GPI-anchor, a core glycan and the phosphorylated disaccharide repeat backbone. Human sera from L. major patients bound amastigote LPG in enzyme-linked immunosorbent assays.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0959-6658
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
419-24
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Structure and antigenicity of the lipophosphoglycan from Leishmania major amastigotes.
pubmed:affiliation
Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't