Linked Life Data

18201129

Source:http://linkedlifedata.com/resource/pubmed/id/18201129

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2008-3-31
pubmed:abstractText
The posterior parietal cortex and the cerebellum are assumed to contribute to anticipatory motor control. Thus, it is reasonable that these areas act as a functional unit. To identify a neural signature of anticipatory motor control, 11 healthy volunteers performed a bimanual finger-tapping task with respect to isochronous (i.e., regular) and randomized (i.e., irregular) auditory pacing. Neuromagnetic activity was recorded using a 122-channel whole-head neuromagnetometer. Functional interaction between spatially distributed brain areas was determined by measures of tap-related phase synchronization. Assuming that (i) the cerebellum predicts sensory events by an internal model and (ii) the PPC maintains this prediction, we hypothesized that functional interaction between both structures varies depending on the predictability of the pacing signal. During isochronous pacing, functional connectivity within a cerebello-diencephalic-parietal network before tap onset was evident, suggesting anticipatory motor control. During randomized pacing, however, functional connectivity after tap onset was increased within a parietal-cerebellar loop, suggesting mismatch detection and update of the internal model. Data of the present study imply that anticipatory motor control is implemented in a network-like manner. Our data agree well with the hypothesis that functional connectivity in a cerebello-diencephalic-parietal loop might be crucial for anticipatory motor control, whereas parietal-cerebellar interaction might be critical for feedback processing.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0898-929X
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
828-40
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Evidence for anticipatory motor control within a cerebello-diencephalic-parietal network.
pubmed:affiliation
Department of Neurology, Heinrich Heine University, Duesseldorf, Germany. bettina.pollok@uni-duesseldorf.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't