| pubmed-article:18200001 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18200001 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:18200001 | lifeskim:mentions | umls-concept:C0027695 | lld:lifeskim |
| pubmed-article:18200001 | lifeskim:mentions | umls-concept:C0160420 | lld:lifeskim |
| pubmed-article:18200001 | lifeskim:mentions | umls-concept:C0752118 | lld:lifeskim |
| pubmed-article:18200001 | lifeskim:mentions | umls-concept:C0679199 | lld:lifeskim |
| pubmed-article:18200001 | lifeskim:mentions | umls-concept:C0302350 | lld:lifeskim |
| pubmed-article:18200001 | lifeskim:mentions | umls-concept:C0728939 | lld:lifeskim |
| pubmed-article:18200001 | lifeskim:mentions | umls-concept:C0332206 | lld:lifeskim |
| pubmed-article:18200001 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:18200001 | pubmed:dateCreated | 2008-3-14 | lld:pubmed |
| pubmed-article:18200001 | pubmed:abstractText | T-type calcium channel blockers have been previously shown to protect glomeruli from hypertension by regulating renal arteriolar tone. To examine whether blockade of these channels has a role in protection against tubulointerstitial damage, we used a stereo-selective T-type calcium channel blocker R(-)-efonidipine and studied its effect on the progression of this type of renal injury in spontaneously hypertensive rats that had undergone subtotal nephrectomy. Treatment with racemic efonidipine for 7 weeks significantly reduced systolic blood pressure and proteinuria. The R(-)-enantiomer, however, had no effect on blood pressure but significantly reduced proteinuria compared to vehicle-treated rats. Both agents blunted the increase in tubulointerstitial fibrosis, renal expression of alpha-smooth muscle actin and vimentin along with transforming growth factor-beta (TGF-beta)-induced renal Rho-kinase activity seen in the control group. Subtotal nephrectomy enhanced renal T-type calcium channel alpha1G subunit expression mimicked in angiotensin II-stimulated mesangial cells or TGF-beta-stimulated proximal tubular cells. Our study shows that T-type calcium channel blockade has renal protective actions that depend not only on hemodynamic effects but also pertain to Rho-kinase activity, tubulointerstitial fibrosis, and epithelial-mesenchymal transitions. | lld:pubmed |
| pubmed-article:18200001 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18200001 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18200001 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18200001 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18200001 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18200001 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18200001 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18200001 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18200001 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18200001 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:18200001 | pubmed:issn | 1523-1755 | lld:pubmed |
| pubmed-article:18200001 | pubmed:author | pubmed-author:SuganoNN | lld:pubmed |
| pubmed-article:18200001 | pubmed:author | pubmed-author:HayashiKK | lld:pubmed |
| pubmed-article:18200001 | pubmed:author | pubmed-author:KandaTT | lld:pubmed |
| pubmed-article:18200001 | pubmed:author | pubmed-author:YoshiokaKK | lld:pubmed |
| pubmed-article:18200001 | pubmed:author | pubmed-author:HasegawaKK | lld:pubmed |
| pubmed-article:18200001 | pubmed:author | pubmed-author:HaroGG | lld:pubmed |
| pubmed-article:18200001 | pubmed:author | pubmed-author:SarutaTT | lld:pubmed |
| pubmed-article:18200001 | pubmed:author | pubmed-author:UtsunomiyaYY | lld:pubmed |
| pubmed-article:18200001 | pubmed:author | pubmed-author:HosoyaTT | lld:pubmed |
| pubmed-article:18200001 | pubmed:author | pubmed-author:YoshizawaTT | lld:pubmed |
| pubmed-article:18200001 | pubmed:author | pubmed-author:SuetsuguYY | lld:pubmed |
| pubmed-article:18200001 | pubmed:author | pubmed-author:HommaKK | lld:pubmed |
| pubmed-article:18200001 | pubmed:author | pubmed-author:TatematsuSS | lld:pubmed |
| pubmed-article:18200001 | pubmed:author | pubmed-author:TokudomeGG | lld:pubmed |
| pubmed-article:18200001 | pubmed:author | pubmed-author:WakinoSS | lld:pubmed |
| pubmed-article:18200001 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18200001 | pubmed:volume | 73 | lld:pubmed |
| pubmed-article:18200001 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18200001 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18200001 | pubmed:pagination | 826-34 | lld:pubmed |
| pubmed-article:18200001 | pubmed:meshHeading | pubmed-meshheading:18200001... | lld:pubmed |
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| pubmed-article:18200001 | pubmed:meshHeading | pubmed-meshheading:18200001... | lld:pubmed |
| pubmed-article:18200001 | pubmed:meshHeading | pubmed-meshheading:18200001... | lld:pubmed |
| pubmed-article:18200001 | pubmed:meshHeading | pubmed-meshheading:18200001... | lld:pubmed |
| pubmed-article:18200001 | pubmed:meshHeading | pubmed-meshheading:18200001... | lld:pubmed |
| pubmed-article:18200001 | pubmed:meshHeading | pubmed-meshheading:18200001... | lld:pubmed |
| pubmed-article:18200001 | pubmed:meshHeading | pubmed-meshheading:18200001... | lld:pubmed |
| pubmed-article:18200001 | pubmed:meshHeading | pubmed-meshheading:18200001... | lld:pubmed |
| pubmed-article:18200001 | pubmed:meshHeading | pubmed-meshheading:18200001... | lld:pubmed |
| pubmed-article:18200001 | pubmed:meshHeading | pubmed-meshheading:18200001... | lld:pubmed |
| pubmed-article:18200001 | pubmed:meshHeading | pubmed-meshheading:18200001... | lld:pubmed |
| pubmed-article:18200001 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18200001 | pubmed:articleTitle | T-type calcium channel blockade as a therapeutic strategy against renal injury in rats with subtotal nephrectomy. | lld:pubmed |
| pubmed-article:18200001 | pubmed:affiliation | Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan. | lld:pubmed |
| pubmed-article:18200001 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18200001 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18200001 | lld:pubmed |
