Source:http://linkedlifedata.com/resource/pubmed/id/18200001
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
7
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pubmed:dateCreated |
2008-3-14
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pubmed:abstractText |
T-type calcium channel blockers have been previously shown to protect glomeruli from hypertension by regulating renal arteriolar tone. To examine whether blockade of these channels has a role in protection against tubulointerstitial damage, we used a stereo-selective T-type calcium channel blocker R(-)-efonidipine and studied its effect on the progression of this type of renal injury in spontaneously hypertensive rats that had undergone subtotal nephrectomy. Treatment with racemic efonidipine for 7 weeks significantly reduced systolic blood pressure and proteinuria. The R(-)-enantiomer, however, had no effect on blood pressure but significantly reduced proteinuria compared to vehicle-treated rats. Both agents blunted the increase in tubulointerstitial fibrosis, renal expression of alpha-smooth muscle actin and vimentin along with transforming growth factor-beta (TGF-beta)-induced renal Rho-kinase activity seen in the control group. Subtotal nephrectomy enhanced renal T-type calcium channel alpha1G subunit expression mimicked in angiotensin II-stimulated mesangial cells or TGF-beta-stimulated proximal tubular cells. Our study shows that T-type calcium channel blockade has renal protective actions that depend not only on hemodynamic effects but also pertain to Rho-kinase activity, tubulointerstitial fibrosis, and epithelial-mesenchymal transitions.
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pubmed:commentsCorrections | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channel Blockers,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channels, T-Type,
http://linkedlifedata.com/resource/pubmed/chemical/Dihydropyridines,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrophenols,
http://linkedlifedata.com/resource/pubmed/chemical/Organophosphorus Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/efonidipine
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1523-1755
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pubmed:author |
pubmed-author:HaroGG,
pubmed-author:HasegawaKK,
pubmed-author:HayashiKK,
pubmed-author:HommaKK,
pubmed-author:HosoyaTT,
pubmed-author:KandaTT,
pubmed-author:SarutaTT,
pubmed-author:SuetsuguYY,
pubmed-author:SuganoNN,
pubmed-author:TatematsuSS,
pubmed-author:TokudomeGG,
pubmed-author:UtsunomiyaYY,
pubmed-author:WakinoSS,
pubmed-author:YoshiokaKK,
pubmed-author:YoshizawaTT
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pubmed:issnType |
Electronic
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pubmed:volume |
73
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
826-34
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pubmed:meshHeading |
pubmed-meshheading:18200001-Animals,
pubmed-meshheading:18200001-Calcium Channel Blockers,
pubmed-meshheading:18200001-Calcium Channels, T-Type,
pubmed-meshheading:18200001-Chronic Disease,
pubmed-meshheading:18200001-Dihydropyridines,
pubmed-meshheading:18200001-Hypertension,
pubmed-meshheading:18200001-Kidney Diseases,
pubmed-meshheading:18200001-Male,
pubmed-meshheading:18200001-Nephrectomy,
pubmed-meshheading:18200001-Nitrophenols,
pubmed-meshheading:18200001-Organophosphorus Compounds,
pubmed-meshheading:18200001-Rats,
pubmed-meshheading:18200001-Rats, Inbred SHR
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pubmed:year |
2008
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pubmed:articleTitle |
T-type calcium channel blockade as a therapeutic strategy against renal injury in rats with subtotal nephrectomy.
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pubmed:affiliation |
Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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