Linked Life Data

18199464

Source:http://linkedlifedata.com/resource/pubmed/id/18199464

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-4-14
pubmed:abstractText
A hospital-based case-control study was conducted near a former black-foot disease (BFD)-endemic area in southwestern Taiwan to examine the possible risk factors and genetic susceptibility for urinary transitional cell carcinoma (TCC). A total of 221 patients with pathologically confirmed TCC and 223 age-sex-matched control subjects from urology outpatient clinics were recruited between 1998 and 2002. The results showed that residency in the BFD area and consumption of well water for more than 10 years was a strong factor on urinary cancer risk (odds ratio [OR],8.16, 95% confidence interval [CI],3.34-19.90, p<0.0001). Dose response relationship between average arsenic concentration in well water and TCC risk was also observed. Cigarette smoking played a relatively minor role in urinary carcinogenesis in this study. The GSTP1 Ile105Val A-->G polymorphism was significantly associated with cancer risk (A/G+G/G: OR=0.60, 95%CI=0.39-0.94, p=0.02), and the effect of Val105 allele was largely confined to the subjects diagnosed earlier than 55 years old (A/G+G/G: OR,0.29; 95% CI, 0.09-0.87, p=0.03). The results suggest that GSTP1 is a candidate for susceptibility locus and Ile105 allele may predispose individuals to early-onset urinary TCC. The GSTM1 null genotype was associated with tumors of high-invasiveness (OR,2.21; 95% CI, 1.34-4.73) as well as with early-onset TCC risk (OR,2.53; 95% CI, 0.97-6.59). Our preliminary results showed the XRCC1 Arg194Trp were associated with arsenic-related urinary TCC and the interaction between the genotype and the exposure was statistically significant. The modulating effect of the GSTM1, GSTT1, GSTP1 Ile105Val, EPHX Tyr113His and XRCC1 Arg280His on arsenic-related TCC risk was also suggestive. These observations implied that impaired metabolism of carcinogenic exposure as well as impaired DNA repair function play an important role in arsenic-related urinary transitional cell carcinogenesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0041-008X
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
228
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
144-55
pubmed:dateRevised
2010-5-21
pubmed:meshHeading
pubmed-meshheading:18199464-Adult, pubmed-meshheading:18199464-Aged, pubmed-meshheading:18199464-Arsenic, pubmed-meshheading:18199464-Carcinoma, Transitional Cell, pubmed-meshheading:18199464-Case-Control Studies, pubmed-meshheading:18199464-DNA-Binding Proteins, pubmed-meshheading:18199464-Environmental Exposure, pubmed-meshheading:18199464-Epoxide Hydrolases, pubmed-meshheading:18199464-Female, pubmed-meshheading:18199464-Genetic Predisposition to Disease, pubmed-meshheading:18199464-Glutathione S-Transferase pi, pubmed-meshheading:18199464-Glutathione Transferase, pubmed-meshheading:18199464-Humans, pubmed-meshheading:18199464-Logistic Models, pubmed-meshheading:18199464-Male, pubmed-meshheading:18199464-Middle Aged, pubmed-meshheading:18199464-Multivariate Analysis, pubmed-meshheading:18199464-Polymorphism, Single Nucleotide, pubmed-meshheading:18199464-Risk Factors, pubmed-meshheading:18199464-Taiwan, pubmed-meshheading:18199464-Urologic Neoplasms, pubmed-meshheading:18199464-Water Pollutants, Chemical
pubmed:year
2008
pubmed:articleTitle
SNPs of GSTM1, T1, P1, epoxide hydrolase and DNA repair enzyme XRCC1 and risk of urinary transitional cell carcinoma in southwestern Taiwan.
pubmed:affiliation
Genomics Research Center, Academia Sinica, 128 Academia Road Section 2, Nankang, Taipei, Taiwan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't