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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1992-7-29
|
| pubmed:abstractText |
Using a multiple-trial, training-to-criterion procedure, the effects of repeated administrations of ginseng stem-leaves saponins (GSLS) on learning and memory of one-way avoidance in rats were studied in shuttle-box. In acquisition, GSLS 10, 30, and 60 mg.kg-1 ip shortened the latency of avoidance in a bell-shaped manner from 1.0 +/- 0.2 s in saline rats to 0.8 +/- 0.5, 0.5 +/- 0.1, 0.8 +/- 0.2 s (d 3 learning) and from 0.9 +/- 0.2 s to 0.8 +/- 0.2, 0.7 +/- 0.1, and 0.8 +/- 0.2 s (10 x 24 h memory), and the best dose was 30 mg.kg-1. GSLS 30 mg.kg-1 ip shortened the latency of avoidance prolonged by scopolamine 0.8 mg.kg-1 sc from 5.2 +/- 1.3 s to 3.9 +/- 0.8 s (d 1 learning acquisition) and from 2.2 +/- 0.6 s to 0.8 +/- 0.3 s (3 x 24 h memory acquisition). In retention, GSLS 30 mg.kg-1 ip shortened the latency prolonged by cycloheximide 2.5 and 5 mg.kg-1 ip from 3.4 +/- 1.0 s to 1.4 +/- 0.5 s (4 h memory) and from 1.6 +/- 0.3 s to 0.9 +/- 0.2 s (24 h memory), and increased the avoidance number decreased by cycloheximide 5 mg.kg-1 from 38.1 +/- 8.8% to 72.4 +/- 10.8% (4 h memory). The results indicate that GSLS facilitated the acquisition of learning and memory in rats, and improved the scopolamine amnesia and cycloheximide amnesia.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antidepressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Cycloheximide,
http://linkedlifedata.com/resource/pubmed/chemical/Ginsenosides,
http://linkedlifedata.com/resource/pubmed/chemical/Saponins,
http://linkedlifedata.com/resource/pubmed/chemical/Scopolamine Hydrobromide
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0253-9756
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
12
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
403-6
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1819893-Amnesia,
pubmed-meshheading:1819893-Animals,
pubmed-meshheading:1819893-Antidepressive Agents,
pubmed-meshheading:1819893-Avoidance Learning,
pubmed-meshheading:1819893-Cycloheximide,
pubmed-meshheading:1819893-Ginsenosides,
pubmed-meshheading:1819893-Memory, Short-Term,
pubmed-meshheading:1819893-Rats,
pubmed-meshheading:1819893-Rats, Inbred Strains,
pubmed-meshheading:1819893-Retention (Psychology),
pubmed-meshheading:1819893-Saponins,
pubmed-meshheading:1819893-Scopolamine Hydrobromide
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Effects of ginseng stem-leaves saponins on one-way avoidance behavior in rats.
|
| pubmed:affiliation |
Department of Traditional Chinese Medicines, Shenyang College of Pharmacy.
|
| pubmed:publicationType |
Journal Article
|