|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2008-1-16
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|
pubmed:abstractText |
We performed functional gene screening, using a siRNA library targeting 8,500 human genes, to identify proteins that are involved in the susceptibility of cells to methylmercury. Screening revealed that downregulation of the gene for phosphatidylinositol glycan class B (PIGB) by siRNA confers resistance to methylmercury in HEK293 cells.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0388-1350
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
32
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
581-3
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|
pubmed:meshHeading |
pubmed-meshheading:18198489-Cell Line,
pubmed-meshheading:18198489-Cell Survival,
pubmed-meshheading:18198489-Dose-Response Relationship, Drug,
pubmed-meshheading:18198489-Drug Resistance,
pubmed-meshheading:18198489-Humans,
pubmed-meshheading:18198489-Mannosyltransferases,
pubmed-meshheading:18198489-Methylmercury Compounds,
pubmed-meshheading:18198489-RNA, Small Interfering,
pubmed-meshheading:18198489-RNA Interference,
pubmed-meshheading:18198489-Transfection
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
siRNA-mediated inhibition of phosphatidylinositol glycan Class B (PIGB) confers resistance to methylmercury in HEK293 cells.
|
|
pubmed:affiliation |
Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
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|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
