| pubmed-article:18198336 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18198336 | lifeskim:mentions | umls-concept:C0015392 | lld:lifeskim |
| pubmed-article:18198336 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:18198336 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:18198336 | lifeskim:mentions | umls-concept:C0812287 | lld:lifeskim |
| pubmed-article:18198336 | lifeskim:mentions | umls-concept:C0035331 | lld:lifeskim |
| pubmed-article:18198336 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:18198336 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:18198336 | lifeskim:mentions | umls-concept:C0456389 | lld:lifeskim |
| pubmed-article:18198336 | lifeskim:mentions | umls-concept:C1707511 | lld:lifeskim |
| pubmed-article:18198336 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:18198336 | pubmed:dateCreated | 2008-1-16 | lld:pubmed |
| pubmed-article:18198336 | pubmed:abstractText | Myc family members play crucial roles in regulating cell proliferation, size, differentiation, and survival during development. We found that N-myc is expressed in retinal progenitor cells, where it regulates proliferation in a cell-autonomous manner. In addition, N-myc coordinates the growth of the retina and eye. Specifically, the retinas of N-myc-deficient mice are hypocellular but are precisely proportioned to the size of the eye. N-myc represses the expression of the cyclin-dependent kinase inhibitor p27Kip1 but acts independently of cyclin D1, the major D-type cyclin in the developing mouse retina. Acute inactivation of N-myc leads to increased expression of p27Kip1, and simultaneous inactivation of p27Kip1 and N-myc rescues the hypocellular phenotype in N-myc-deficient retinas. N-myc is not required for retinal cell fate specification, differentiation, or survival. These data represent the first example of a role for a Myc family member in retinal development and the first characterization of a mouse model in which the hypocellular retina is properly proportioned to the other ocular structures. We propose that N-myc lies upstream of the cell cycle machinery in the developing mouse retina and thus coordinates the growth of both the retina and eye through extrinsic cues. | lld:pubmed |
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| pubmed-article:18198336 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18198336 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18198336 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18198336 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18198336 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18198336 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:18198336 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:18198336 | pubmed:author | pubmed-author:AmentA SAS | lld:pubmed |
| pubmed-article:18198336 | pubmed:author | pubmed-author:RousselMartin... | lld:pubmed |
| pubmed-article:18198336 | pubmed:author | pubmed-author:ZindyFrederiq... | lld:pubmed |
| pubmed-article:18198336 | pubmed:author | pubmed-author:EisenmanRober... | lld:pubmed |
| pubmed-article:18198336 | pubmed:author | pubmed-author:DyerMichael... | lld:pubmed |
| pubmed-article:18198336 | pubmed:author | pubmed-author:KnoepflerPaul... | lld:pubmed |
| pubmed-article:18198336 | pubmed:author | pubmed-author:ZhangJiakunJ | lld:pubmed |
| pubmed-article:18198336 | pubmed:author | pubmed-author:PoundsStanley... | lld:pubmed |
| pubmed-article:18198336 | pubmed:author | pubmed-author:MartinsRodrig... | lld:pubmed |
| pubmed-article:18198336 | pubmed:author | pubmed-author:DonovanStacyS | lld:pubmed |
| pubmed-article:18198336 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18198336 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:18198336 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:18198336 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18198336 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18198336 | pubmed:pagination | 179-93 | lld:pubmed |
| pubmed-article:18198336 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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