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rdf:type |
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lifeskim:mentions |
umls-concept:C0004927,
umls-concept:C0017337,
umls-concept:C0026809,
umls-concept:C0033684,
umls-concept:C0242299,
umls-concept:C0597357,
umls-concept:C0682972,
umls-concept:C1280500,
umls-concept:C1367690,
umls-concept:C1426330,
umls-concept:C1428424,
umls-concept:C1442161,
umls-concept:C1948027
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pubmed:dateCreated |
2008-2-14
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pubmed:abstractText |
The orphan GPCR MrgE is one of an extended family of GPCRs that are expressed in dorsal root ganglia (DRG). Based on these expression patterns it has been suggested that GPCRs like MrgE may play a role in nociception however, to date, no direct supporting evidence has emerged. We generated mutant mice lacking MrgE and examined the effects of deletion of this gene in three pain behavioural models. The effect of MrgE gene deletion on expression of Mrgs and genes involved in sensory neurone function was also investigated.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18197975-10448219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18197975-10534603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18197975-11551509,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18197975-12351708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18197975-12397184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18197975-12915402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18197975-15163697,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18197975-15629699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18197975-15710235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18197975-16246453,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18197975-16282220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18197975-16446141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18197975-16481427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18197975-16500002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18197975-16979137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18197975-17442834,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18197975-17553143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18197975-17767492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18197975-17965656
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1744-8069
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18197975-Animals,
pubmed-meshheading:18197975-Behavior, Animal,
pubmed-meshheading:18197975-Female,
pubmed-meshheading:18197975-Ganglia, Spinal,
pubmed-meshheading:18197975-Gene Deletion,
pubmed-meshheading:18197975-Gene Expression Regulation,
pubmed-meshheading:18197975-Male,
pubmed-meshheading:18197975-Mice,
pubmed-meshheading:18197975-Mice, Inbred C57BL,
pubmed-meshheading:18197975-Mice, Knockout,
pubmed-meshheading:18197975-Motor Activity,
pubmed-meshheading:18197975-Neurons, Afferent,
pubmed-meshheading:18197975-Pain,
pubmed-meshheading:18197975-Pain Measurement,
pubmed-meshheading:18197975-Rats,
pubmed-meshheading:18197975-Receptors, G-Protein-Coupled
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pubmed:year |
2008
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pubmed:articleTitle |
The effect of deletion of the orphan G - protein coupled receptor (GPCR) gene MrgE on pain-like behaviours in mice.
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pubmed:affiliation |
Pain Therapeutics, Discovery Biology, Pfizer Global Research and Development, Sandwich, Kent CT13 9NJ, UK. Peter.J.Cox@pfizer.com
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pubmed:publicationType |
Journal Article
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