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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
49-50
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pubmed:dateCreated |
2008-1-16
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|
pubmed:abstractText |
nitric oxide (NO) plays an important role in the regulation of cardiovascular and glucose homeostasis. Mice lacking the gene encoding the neuronal isoform of nitric oxide synthase (nNOS) are insulin-resistant, but the underlying mechanism is unknown. nNOS is expressed in skeletal muscle tissue where it may regulate glucose uptake. Alternatively, nNOS driven NO synthesis may facilitate skeletal muscle perfusion and substrate delivery. Finally, nNOS dependent NO in the central nervous system may facilitate glucose disposal by decreasing sympathetic nerve activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1424-7860
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
22
|
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pubmed:volume |
137
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
700-4
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pubmed:dateRevised |
2011-2-15
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pubmed:meshHeading |
pubmed-meshheading:18197485-Adrenergic alpha-Antagonists,
pubmed-meshheading:18197485-Animals,
pubmed-meshheading:18197485-Blood Glucose,
pubmed-meshheading:18197485-Female,
pubmed-meshheading:18197485-Glucose Clamp Technique,
pubmed-meshheading:18197485-Insulin Resistance,
pubmed-meshheading:18197485-Male,
pubmed-meshheading:18197485-Mice,
pubmed-meshheading:18197485-Mice, Inbred C57BL,
pubmed-meshheading:18197485-Mice, Knockout,
pubmed-meshheading:18197485-Muscle, Skeletal,
pubmed-meshheading:18197485-Nitric Oxide Synthase Type I,
pubmed-meshheading:18197485-Phentolamine
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pubmed:year |
2007
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pubmed:articleTitle |
Insulin resistance in mice lacking neuronal nitric oxide synthase is related to an alpha-adrenergic mechanism.
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pubmed:affiliation |
Department of Internal Medicine and Botnar Center for Clinical Research, CHUV, Lausanne, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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