Linked Life Data

18197166

Source:http://linkedlifedata.com/resource/pubmed/id/18197166

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-1-18
pubmed:abstractText
MicroRNAs constitute a large family of small, approximately 21-nucleotide-long, non-coding RNAs that have emerged as key post-transcriptional regulators of gene expression in metazoans and plants. In mammals, microRNAs are predicted to control the activity of approximately 30% of all protein-coding genes, and have been shown to participate in the regulation of almost every cellular process investigated so far. By base pairing to mRNAs, microRNAs mediate translational repression or mRNA degradation. This Review summarizes the current understanding of the mechanistic aspects of microRNA-induced repression of translation and discusses some of the controversies regarding different modes of microRNA function.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1471-0064
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
102-14
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?
pubmed:affiliation
Friedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland. witold.filipowicz@fmi.ch
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't