Source:http://linkedlifedata.com/resource/pubmed/id/18195530
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2008-1-15
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pubmed:abstractText |
The objective of this study was to clarify the clinical features of long-time survivors with unresectable pancreatic cancer treated by gemcitabine(GEM)alone and to predict survival time by carbohydrate antigen(CA)19-9, enhanced computed tomography(CT), and 18F-fluoro-2-deoxy-D-glucose positron emission tomography(FDG-PET) in monitoring the response to chemotherapy. Twenty-one patients with unresectable pancreatic cancer were enrolled in this study. All patients were evaluated by serum CA19-9 level, tumor size of CT, maximum standardized uptake value (SUVmax)with FDG-PET and other factors before chemotherapy(GEM alone at a dose of 1,000 mg/m(2) weekly x 3 followed by 1 week of rest), and they received chemotherapy until obviously progressive disease. Serum CA19-9, tumor size of CT and SUVmax with PET were measured after three courses of chemotherapy in ten patients. We compared these three modalities in terms of two points: Which is the best modality to predict survival time ? Which is the best monitoring modality to evaluate the efficacy of chemotherapy on unresectable pancreatic cancer ? A significant difference in survival time was not found between high level group and low level group of serum CA19-9 level and SUVmax with FDG-PET and also longest length of tumor by enhanced CT. In ten patients we evaluated the response rate of each parameter CA19-9(IU/mL), CT(longest length of tumor), and SUVmax with FDG-PET. We defined the response rate(pretreatment level of CA19-9 or longest length of tumor or SUVmax-after 3 courses chemotherapy level of CA19-9 or longest length of tumor or SUVmax/pretreatment level of CA19-9 or longest length of tumor or SUVmax). Response rate of CA19-9 was significantly correlated with survival time(r=0.633, p=0.0481). However, the response rate of SUVmax with FDG-PET had no significant correlation with survival time(r=0.019, p=0.9630). In the present study, the response rate of CA19-9 is the best monitoring modality to evaluate the efficacy of chemotherapy.
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pubmed:language |
jpn
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0385-0684
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pubmed:author |
pubmed-author:AbeYasunobuY,
pubmed-author:FujisawaToshioT,
pubmed-author:FujitaKojiK,
pubmed-author:InamoriMasahikoM,
pubmed-author:KirikoshiHiroyukiH,
pubmed-author:KobayashiNoritoshiN,
pubmed-author:KubotaKennsukeK,
pubmed-author:NakajimaAtsushiA,
pubmed-author:SaitoSatoruS,
pubmed-author:TakahashiHirokazuH,
pubmed-author:YonedaMasatoM
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pubmed:issnType |
Print
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
65-70
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pubmed:meshHeading |
pubmed-meshheading:18195530-Aged,
pubmed-meshheading:18195530-Female,
pubmed-meshheading:18195530-Fluorodeoxyglucose F18,
pubmed-meshheading:18195530-Humans,
pubmed-meshheading:18195530-Male,
pubmed-meshheading:18195530-Middle Aged,
pubmed-meshheading:18195530-Pancreatic Neoplasms,
pubmed-meshheading:18195530-Positron-Emission Tomography,
pubmed-meshheading:18195530-Survival Rate,
pubmed-meshheading:18195530-Tomography, X-Ray Computed,
pubmed-meshheading:18195530-Tumor Markers, Biological
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pubmed:year |
2008
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pubmed:articleTitle |
[Which is the best monitoring study (tumor marker, computed tomography or 18F-fluoro-2-deoxy-D-glucose positron emission tomography) to evaluate efficacy of chemotherapy on unresectable pancreatic cancer ?].
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pubmed:affiliation |
Gastroenterology Division, Yokohama City University Hospital, Yokohama City University Graduate School of Medicine.
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pubmed:publicationType |
Journal Article,
English Abstract
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