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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2008-3-17
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pubmed:abstractText |
Myocardial function is severely compromised during sepsis. Several underlying mechanisms have been proposed. The innate immune system, i.e. toll-like receptor (TLR) 2 and 4, significantly contributes to cardiac dysfunction. Little is known regarding TLR9 and its pathogenic ligand bacterial DNA in the myocardium. We therefore studied the role of TLR9 in myocardial inflammation and cardiac contractility.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CPG-oligonucleotide,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1beta,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Nos2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Oligodeoxyribonucleotides,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Tlr9 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 9,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0008-6363
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pubmed:author |
pubmed-author:BaumgartenGeorgG,
pubmed-author:BoehmOlafO,
pubmed-author:DreinerUlrikeU,
pubmed-author:EhrentrautHeidiH,
pubmed-author:FinkKlausK,
pubmed-author:GrohéChristianC,
pubmed-author:HoeftAndreasA,
pubmed-author:KnuefermannPascalP,
pubmed-author:KochAlexanderA,
pubmed-author:KringsPeterP,
pubmed-author:MeyerRainerR,
pubmed-author:RüdigerMyriamM,
pubmed-author:SchwederskiMarkusM,
pubmed-author:VeltenMarkusM,
pubmed-author:ZacharowskiKaiK
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
78
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
26-35
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:18194990-Animals,
pubmed-meshheading:18194990-Cells, Cultured,
pubmed-meshheading:18194990-Cytokines,
pubmed-meshheading:18194990-DNA, Bacterial,
pubmed-meshheading:18194990-Disease Models, Animal,
pubmed-meshheading:18194990-Immunity, Innate,
pubmed-meshheading:18194990-Interleukin-1beta,
pubmed-meshheading:18194990-Interleukin-6,
pubmed-meshheading:18194990-Mice,
pubmed-meshheading:18194990-Mice, Inbred C57BL,
pubmed-meshheading:18194990-Mice, Knockout,
pubmed-meshheading:18194990-Myocardial Contraction,
pubmed-meshheading:18194990-Myocarditis,
pubmed-meshheading:18194990-Myocardium,
pubmed-meshheading:18194990-NF-kappa B,
pubmed-meshheading:18194990-Nitric Oxide Synthase Type II,
pubmed-meshheading:18194990-Oligodeoxyribonucleotides,
pubmed-meshheading:18194990-RNA, Messenger,
pubmed-meshheading:18194990-Sarcomeres,
pubmed-meshheading:18194990-Sepsis,
pubmed-meshheading:18194990-Time Factors,
pubmed-meshheading:18194990-Toll-Like Receptor 9,
pubmed-meshheading:18194990-Tumor Necrosis Factor-alpha
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pubmed:year |
2008
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pubmed:articleTitle |
Bacterial DNA induces myocardial inflammation and reduces cardiomyocyte contractility: role of toll-like receptor 9.
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pubmed:affiliation |
Department for Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Sigmund-Freud-Strasse 25, Bonn 53105, Germany. pascal.knuefermann@ukb.uni-bonn.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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