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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2008-2-22
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pubmed:abstractText |
In the life cycle of Leishmania within the alimentary canal of sand flies the parasites have to survive the hostile environment of blood meal digestion, escape the blood bolus and attach to the midgut epithelium before differentiating into the infective metacyclic stages. The molecular interactions between the Leishmania parasites and the gut of the sand fly are poorly understood. In the present work we sequenced five cDNA libraries constructed from midgut tissue from the sand fly Lutzomyia longipalpis and analyzed the transcripts present following sugar feeding, blood feeding and after the blood meal has been processed and excreted, both in the presence and absence of Leishmania infantum chagasi.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18194529-10207004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18194529-10802651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18194529-11136609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18194529-11434553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18194529-11934758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18194529-12177149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18194529-12213235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18194529-12213246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18194529-12535675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18194529-14623973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18194529-15153308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18194529-15557638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18194529-15608175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18194529-16540402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18194529-16597201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18194529-16843727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18194529-16887324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18194529-17760985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18194529-2658086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18194529-6696182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18194529-8344906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18194529-9707603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18194529-9836311
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2164
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
15
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18194529-Amino Acid Sequence,
pubmed-meshheading:18194529-Animals,
pubmed-meshheading:18194529-Anti-Bacterial Agents,
pubmed-meshheading:18194529-Carbohydrates,
pubmed-meshheading:18194529-Cluster Analysis,
pubmed-meshheading:18194529-Digestion,
pubmed-meshheading:18194529-Enzyme Inhibitors,
pubmed-meshheading:18194529-Enzymes,
pubmed-meshheading:18194529-Gastrointestinal Tract,
pubmed-meshheading:18194529-Gene Expression Profiling,
pubmed-meshheading:18194529-Gene Expression Regulation,
pubmed-meshheading:18194529-Gene Library,
pubmed-meshheading:18194529-Insect Proteins,
pubmed-meshheading:18194529-Leishmania infantum,
pubmed-meshheading:18194529-Molecular Sequence Data,
pubmed-meshheading:18194529-Oxidative Stress,
pubmed-meshheading:18194529-Phylogeny,
pubmed-meshheading:18194529-Psychodidae,
pubmed-meshheading:18194529-RNA, Messenger,
pubmed-meshheading:18194529-Sequence Alignment,
pubmed-meshheading:18194529-Sequence Analysis, DNA
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pubmed:year |
2008
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pubmed:articleTitle |
The midgut transcriptome of Lutzomyia longipalpis: comparative analysis of cDNA libraries from sugar-fed, blood-fed, post-digested and Leishmania infantum chagasi-infected sand flies.
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pubmed:affiliation |
Vector Molecular Biology Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA. rjochim@niaid.nih.gov
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, N.I.H., Intramural
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