Linked Life Data

18192968

Source:http://linkedlifedata.com/resource/pubmed/id/18192968

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-2-26
pubmed:abstractText
Two independent pathways of vulvar carcinogenesis have currently been identified, one related to infection with mucosal human papillomaviruses (HPVs) and a second related to chronic inflammatory or autoimmune processes. The goal of the study was to examine a possible role of cutaneous HPVs from the beta genus in vulvar carcinogenesis and to evaluate the distribution of intratypic variants of HPV 16 in HPV 16-positive vulvar cancer. Consecutive cases of vulvar carcinoma were retrieved from the files and included the following histologic subtypes: keratinizing (n=21), basaloid (n=7), warty (n=1), mixed basaloid-warty (n=4), verrucous (n=4), keratoacanthoma (n=1), basal cell carcinoma (n=1). All tumors were microdissected and tested for 25 beta HPV types and 25 mucosal HPV types. Cases identified as positive for HPV 16 were further tested for intratypic variants. All cases were immunostained for p16INK4a. Beta HPVs were not detected in any of the tumor cases. Mucosal HPVs were detected in all but one basaloid/warty carcinomas; of these, nine cases (82%) were positive for HPV 16, including five European subtypes, one African subtype, one North American subtype and two indeterminate subtypes. Two of four verrucous carcinomas were positive for HPV 6. Mucosal HPVs were not detected in keratinizing carcinomas, keratoacanthoma and basal cell carcinoma. All cases of basaloid/warty carcinomas, but none of the remaining tumors, overexpressed p16INK4a protein. Our data do not support a role of beta HPVs in the pathogenesis of vulvar carcinoma. The study reaffirms the role of mucosal HPVs, in particular that of HPV 16, in the pathogenesis of basaloid and warty tumor subtypes. The HPV 16 intratypic variation showed correlation with patients' ethnic background. P16INK4a immunostaining seems to be a sensitive and specific marker of vulvar carcinomas positive for oncogenic mucosal HPVs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0893-3952
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
334-44
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:18192968-Carcinoma, Squamous Cell, pubmed-meshheading:18192968-Carcinoma, Verrucous, pubmed-meshheading:18192968-Cyclin-Dependent Kinase Inhibitor p16, pubmed-meshheading:18192968-DNA, Viral, pubmed-meshheading:18192968-Female, pubmed-meshheading:18192968-Human papillomavirus 16, pubmed-meshheading:18192968-Humans, pubmed-meshheading:18192968-Mucous Membrane, pubmed-meshheading:18192968-Oncogene Proteins, Viral, pubmed-meshheading:18192968-Organ Specificity, pubmed-meshheading:18192968-Papillomaviridae, pubmed-meshheading:18192968-Papillomavirus E7 Proteins, pubmed-meshheading:18192968-Papillomavirus Infections, pubmed-meshheading:18192968-Repressor Proteins, pubmed-meshheading:18192968-Skin, pubmed-meshheading:18192968-Tumor Virus Infections, pubmed-meshheading:18192968-Vulvar Neoplasms
pubmed:year
2008
pubmed:articleTitle
Prevalence of mucosal and cutaneous human papillomaviruses in different histologic subtypes of vulvar carcinoma.
pubmed:affiliation
DDL Diagnostic Laboratory, Voorburg, The Netherlands.
pubmed:publicationType
Journal Article