Linked Life Data

18191480

Source:http://linkedlifedata.com/resource/pubmed/id/18191480

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-3-10
pubmed:abstractText
Mutations in genes encoding cytoskeletal proteins participate in the pathogenesis of familial dilated cardiomyopathy (fDCM). Additional factors including inflammatory reactions are believed to play a role in deterioration of left-ventricular function. An association of inflammatory fDCM with the HSPA1B 1267 A-->G polymorphism was identified. Since the HSPA1B 1267 A-->G polymorphism has been associated with autoimmune disorders, this finding might point to a pathogenetic role of (auto-) immune phenomena in distinct forms of familial DCM. HSPA1B 1267 A-->G is part of an extended DR3 haplotype explaining the strong association between both alleles. Recombinant haplotype mapping including neighboring genes might aid in identification and classification of susceptibility genes which in turn can point to the not yet identified causative agent.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1874-1754
pubmed:author
pubmed:issnType
Electronic
pubmed:day
20
pubmed:volume
133
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
126-8
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
HSPA1B polymorphism in familial forms of inflammatory dilated cardiomyopathy.
pubmed:publicationType
Letter