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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2008-10-17
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pubmed:abstractText |
Growing evidence indicates that 5-hydrohytryptamine (5-HT) receptors mediate learning and memory. Particularly interesting are 5-HT(6) and 5-HT(7) receptors, which are localized in brain areas involved in memory formation. Interestingly, recently selective 5-HT(6) and 5-HT(7) receptor agonists and antagonists have become available. Previous evidence indicates that 5-HT(6) or 5-HT(7) receptors antagonists had no effects, improved memory formation and/or reversed amnesia. Herein, the effects of EMD (a 5-HT(6) receptor agonist) and AS19 (a 5-HT(7) receptor agonist) in the associative learning task of autoshaping were studied. Post-training systemic administration of EMD (1-10 mg/kg) or AS19 (1-10 mg/kg) were tested in short-term memory (STM) and long-term memory (LTM). Results showed that only EMD 5.0mg/kg impaired both STM and LTM. AS19 at 1-10 mg/kg significantly impaired STM but not LTM. In those groups used to test only LTM, EMD impaired it; while AS19 improved LTM. Moreover, in the interaction experiments, the STM EMD-impairment effect was partially reversed by the selective 5-HT(6) receptor antagonist SB-399885 (10 mg/kg). The STM AS19-impairment effect (5.0 mg/kg) was not altered by the selective 5-HT(1A) antagonist WAY 100635 (0.3 mg/kg) but reversed by the selective 5-HT(7) receptor antagonist SB-269970 (10.0 mg/kg). The AS19-SB-269970 combination impaired LTM. Taken together these data suggest that the stimulation of 5-HT(6) impaired both STM and LTM. 5-HT(7) receptors stimulation impaired STM but improved LTM. And these results are discussed in the context of their possible neural bases.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/5-chloro-2-methyl-3-(1,2,3,6-tetrahy...,
http://linkedlifedata.com/resource/pubmed/chemical/AS 19 compound,
http://linkedlifedata.com/resource/pubmed/chemical/Indoles,
http://linkedlifedata.com/resource/pubmed/chemical/Phenols,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/SB 269970,
http://linkedlifedata.com/resource/pubmed/chemical/SB-399885,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Receptor Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrahydronaphthalenes,
http://linkedlifedata.com/resource/pubmed/chemical/WAY 100635,
http://linkedlifedata.com/resource/pubmed/chemical/serotonin 6 receptor,
http://linkedlifedata.com/resource/pubmed/chemical/serotonin 7 receptor
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1872-7549
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
16
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pubmed:volume |
195
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
112-9
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:18191236-Analysis of Variance,
pubmed-meshheading:18191236-Animals,
pubmed-meshheading:18191236-Association Learning,
pubmed-meshheading:18191236-Behavior, Animal,
pubmed-meshheading:18191236-Dose-Response Relationship, Drug,
pubmed-meshheading:18191236-Indoles,
pubmed-meshheading:18191236-Injections, Intraperitoneal,
pubmed-meshheading:18191236-Injections, Subcutaneous,
pubmed-meshheading:18191236-Male,
pubmed-meshheading:18191236-Memory,
pubmed-meshheading:18191236-Memory, Short-Term,
pubmed-meshheading:18191236-Phenols,
pubmed-meshheading:18191236-Piperazines,
pubmed-meshheading:18191236-Pyrazoles,
pubmed-meshheading:18191236-Pyridines,
pubmed-meshheading:18191236-Rats,
pubmed-meshheading:18191236-Rats, Wistar,
pubmed-meshheading:18191236-Receptors, Serotonin,
pubmed-meshheading:18191236-Serotonin Antagonists,
pubmed-meshheading:18191236-Serotonin Receptor Agonists,
pubmed-meshheading:18191236-Sulfonamides,
pubmed-meshheading:18191236-Tetrahydronaphthalenes
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pubmed:year |
2008
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pubmed:articleTitle |
The effects of the 5-HT(6) receptor agonist EMD and the 5-HT(7) receptor agonist AS19 on memory formation.
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pubmed:affiliation |
Dept. of Pharmacobiology, CINVESTAV, México City 14330, Mexico. ameneses@msn.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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