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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0019682,
umls-concept:C0019699,
umls-concept:C0019704,
umls-concept:C0026473,
umls-concept:C0039725,
umls-concept:C0185117,
umls-concept:C0237401,
umls-concept:C0332281,
umls-concept:C0497327,
umls-concept:C2705716,
umls-concept:C2745888,
umls-concept:C2911684
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pubmed:issue |
1-2
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pubmed:dateCreated |
2008-4-21
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pubmed:abstractText |
HIV Associated Dementia (HAD) is a complication of HIV infection in developed countries and is still poorly defined in resource-limited settings. In this study we investigated the expression of the monocyte phenotype CD14CD16HLADR and the inflammatory profiles in monocytes supernatants by surface-enhanced laser desorption/ionization-time of flight (SELDI-TOF) mass spectrometry in a cohort of HAD and non-HAD Thai volunteers prior to the initiation of ARV. The CD14CD16HLADR phenotype was significantly increased in monocytes from HAD and non-HAD versus negative controls, but there was no difference in phenotype and in the secretion protein profiles between the two seropositive groups. In addition, monocytes supernatants from HAD and non-HAD did not induced apoptosis or cell death in brain aggregate culture. In conclusion it appears that HAD in Thai individuals has a different immunological profile then in North America cohorts.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0165-5728
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pubmed:author |
pubmed-author:ChitpatimaSuwicha TST,
pubmed-author:ChuenchitraThippawanT,
pubmed-author:GongwonSiriphanS,
pubmed-author:KimJerome HJH,
pubmed-author:NidhinandanaSamartS,
pubmed-author:NitayaphanSorachaiS,
pubmed-author:ParisRobertR,
pubmed-author:PulliamLynnL,
pubmed-author:Ratto-KimSilviaS,
pubmed-author:RempelHansH,
pubmed-author:ShikumaCecilia MCM,
pubmed-author:ShiramizuBruce TBT,
pubmed-author:SithinamsuwanPasiriP,
pubmed-author:Southeast Asia Research Collaboration with the University of Hawaii...,
pubmed-author:SukwitSuchitraS,
pubmed-author:SunBingB,
pubmed-author:ThitivichianlertSatapornS,
pubmed-author:ValcourVictor GVG,
pubmed-author:WilliamsKennethK,
pubmed-author:de SouzaMark SMS
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pubmed:issnType |
Print
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pubmed:volume |
195
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
100-7
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pubmed:meshHeading |
pubmed-meshheading:18191233-AIDS Dementia Complex,
pubmed-meshheading:18191233-Adult,
pubmed-meshheading:18191233-Antigens, CD4,
pubmed-meshheading:18191233-CD4 Lymphocyte Count,
pubmed-meshheading:18191233-CD4-Positive T-Lymphocytes,
pubmed-meshheading:18191233-Cohort Studies,
pubmed-meshheading:18191233-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:18191233-Female,
pubmed-meshheading:18191233-HIV Infections,
pubmed-meshheading:18191233-HIV-1,
pubmed-meshheading:18191233-Humans,
pubmed-meshheading:18191233-Male,
pubmed-meshheading:18191233-Monocytes,
pubmed-meshheading:18191233-Spectrometry, Mass, Matrix-Assisted Laser...,
pubmed-meshheading:18191233-Statistics, Nonparametric,
pubmed-meshheading:18191233-Thailand,
pubmed-meshheading:18191233-Viral Load
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pubmed:year |
2008
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pubmed:articleTitle |
Expression of monocyte markers in HIV-1 infected individuals with or without HIV associated dementia and normal controls in Bangkok Thailand.
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pubmed:affiliation |
Hawaii AIDS Clinical Research Program, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, United States. silvia.kim@afrims.org
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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