Linked Life Data

18190446

Source:http://linkedlifedata.com/resource/pubmed/id/18190446

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-1-14
pubmed:abstractText
We report the case of an immunocompetent 79-year-old white man with a history of melanoma in situ on the back with a collision tumor composed of a Merkel cell carcinoma (MCC) and lentigo maligna melanoma on the left cheek. The cells of the MCC expressed cytokeratin 20 (CK 20) in a diffuse cytoplasmic pattern, AE1 and AE3 in a perinuclear dot-like pattern and diffusely with neuron-specific enolase. The tumor cells of the MCC failed to express thyroid transcription factor-1. The atypical melanocytes of lentigo maligna melanoma expressed Melan-A and S-100. At the same visit, a lentigo maligna was diagnosed by excisional biopsy on the right cheek. The variability in expression of CK 20, AE1 and AE3 in MCC are reviewed. Prior reports of MCC in collision with non-melanoma skin cancers are reviewed. Additionally, the role of immunosuppression in the development of MCC is considered.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1600-0560
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
203-6
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Collision tumor composed of Merkel cell carcinoma and lentigo maligna melanoma.
pubmed:affiliation
Department of Dermatopathology, Geisinger Medical Center, Danville, PA 17821, USA. sethbforman@gmail.com
pubmed:publicationType
Journal Article, Case Reports