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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2008-1-14
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pubmed:abstractText |
HLA-DRB1*0101 is associated with susceptibility to human T lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Here, we used a synthetic tetramer of DRB1*0101 and its epitope peptide to analyze HTLV-1-specific CD4(+) T cells ex vivo. The frequency of tetramer(+)CD4(+) T cells was significantly greater in patients with HAM/TSP than in healthy HTLV-1 carriers (HCs) at a given proviral load and correlated with HTLV-1 tax messenger RNA expression in HCs but not in patients with HAM/TSP. These cells displayed an early to intermediate effector memory phenotype and were preferentially infected by HTLV-1. T cell receptor gene analyses of 2 unrelated DRB1*0101-positive patients with HAM/TSP showed similar Vbeta repertoires and amino acid motifs in complementarity-determining region 3. Our data suggest that efficient clonal expansion of virus-specific CD4(+) T cells in patients with HAM/TSP does not simply reflect higher viral burden but rather reflects a rapid turnover caused by preferential infection and/or in vivo stimulation by major histocompatibility complex-peptide complexes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/HLA-A Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DRB1*01:01 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DRB1 Chains,
http://linkedlifedata.com/resource/pubmed/chemical/HTLV-I Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II,
http://linkedlifedata.com/resource/pubmed/chemical/Immunodominant Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-1899
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pubmed:author |
pubmed-author:BanghamCharles R MCR,
pubmed-author:GoonPeter KPK,
pubmed-author:IzumoShujiS,
pubmed-author:KubotaRyujiR,
pubmed-author:NoseHirohisaH,
pubmed-author:OharaYoshiroY,
pubmed-author:OsameMitsuhiroM,
pubmed-author:SaitoMinekiM,
pubmed-author:SethNilufer PNP,
pubmed-author:TanakaYuetsuY,
pubmed-author:UsukuKoichiroK,
pubmed-author:WucherpfennigKai WKW
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
196
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1761-72
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18190256-Alleles,
pubmed-meshheading:18190256-Amino Acid Sequence,
pubmed-meshheading:18190256-CD4-Positive T-Lymphocytes,
pubmed-meshheading:18190256-Female,
pubmed-meshheading:18190256-Genes, pX,
pubmed-meshheading:18190256-Genetic Predisposition to Disease,
pubmed-meshheading:18190256-HLA-A Antigens,
pubmed-meshheading:18190256-HLA-DRB1 Chains,
pubmed-meshheading:18190256-HTLV-I Antigens,
pubmed-meshheading:18190256-Histocompatibility Antigens Class II,
pubmed-meshheading:18190256-Human T-lymphotropic virus 1,
pubmed-meshheading:18190256-Humans,
pubmed-meshheading:18190256-Immunodominant Epitopes,
pubmed-meshheading:18190256-Leukocytes, Mononuclear,
pubmed-meshheading:18190256-Male,
pubmed-meshheading:18190256-Middle Aged,
pubmed-meshheading:18190256-Molecular Sequence Data,
pubmed-meshheading:18190256-Paraparesis, Tropical Spastic,
pubmed-meshheading:18190256-Phenotype,
pubmed-meshheading:18190256-RNA, Messenger,
pubmed-meshheading:18190256-Receptors, Antigen, T-Cell,
pubmed-meshheading:18190256-Viral Load
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pubmed:year |
2007
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pubmed:articleTitle |
Ex vivo analysis of human T lymphotropic virus type 1-specific CD4+ cells by use of a major histocompatibility complex class II tetramer composed of a neurological disease-susceptibility allele and its immunodominant peptide.
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pubmed:affiliation |
Department of Neurology and Geriatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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