Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-1-23
pubmed:abstractText
This study examined the effects of baicalin, a bioactive flavonoid isolated from Scutellariae Radix, on carbon tetrachloride (CCl(4))-induced liver injury. Mice were treated intraperitoneally with 0.5 ml/kg CCl(4) and different groups of animals received 25, 50, 100, and 200 mg/kg baicalin. At 24 h after the CCl(4) treatment, the level of serum aminotransferases and lipid peroxidation was significantly elevated, whereas the hepatic glutathione content was decreased. These changes were attenuated by baicalin. The histological studies showed that baicalin inhibited the portal inflammation, centrizonal necrosis, and Kupffer cell hyperplasia, which are the three most common characteristics of CCl(4)-induced liver damage. The serum level and mRNA expression of tumor necrosis factor-alpha were markedly increased by the CCl(4) treatment but suppressed by baicalin. The mRNA and protein expression levels of inducible nitric oxide synthase and heme oxygenase-1 increased significantly at 24 h after the CCl(4) treatment. Baicalin attenuated the increase in the protein and gene expression of inducible nitric oxide synthase but augmented the increase in those of heme oxygenase-1. These findings suggest that baicalin protects hepatocytes from the oxidative damage caused by CCl(4), and this protection is likely due to the induction of HO-1 expression and the inhibition of the proinflammatory mediators.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants, http://linkedlifedata.com/resource/pubmed/chemical/Carbon Tetrachloride, http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2, http://linkedlifedata.com/resource/pubmed/chemical/Flavonoids, http://linkedlifedata.com/resource/pubmed/chemical/Glutathione, http://linkedlifedata.com/resource/pubmed/chemical/Heme Oxygenase-1, http://linkedlifedata.com/resource/pubmed/chemical/Hmox1 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II, http://linkedlifedata.com/resource/pubmed/chemical/Nos2 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Ptgs2 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/Transaminases, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha, http://linkedlifedata.com/resource/pubmed/chemical/baicalin
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1347-8613
pubmed:author
pubmed:issnType
Print
pubmed:volume
106
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
136-43
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:18187930-Animals, pubmed-meshheading:18187930-Antioxidants, pubmed-meshheading:18187930-Carbon Tetrachloride, pubmed-meshheading:18187930-Cyclooxygenase 2, pubmed-meshheading:18187930-Disease Models, Animal, pubmed-meshheading:18187930-Dose-Response Relationship, Drug, pubmed-meshheading:18187930-Drug-Induced Liver Injury, pubmed-meshheading:18187930-Flavonoids, pubmed-meshheading:18187930-Glutathione, pubmed-meshheading:18187930-Heme Oxygenase-1, pubmed-meshheading:18187930-Lipid Peroxidation, pubmed-meshheading:18187930-Liver, pubmed-meshheading:18187930-Liver Diseases, pubmed-meshheading:18187930-Male, pubmed-meshheading:18187930-Membrane Proteins, pubmed-meshheading:18187930-Mice, pubmed-meshheading:18187930-Mice, Inbred ICR, pubmed-meshheading:18187930-Nitric Oxide Synthase Type II, pubmed-meshheading:18187930-Oxidative Stress, pubmed-meshheading:18187930-RNA, Messenger, pubmed-meshheading:18187930-Time Factors, pubmed-meshheading:18187930-Transaminases, pubmed-meshheading:18187930-Tumor Necrosis Factor-alpha
pubmed:year
2008
pubmed:articleTitle
Protective effect of baicalin against carbon tetrachloride-induced acute hepatic injury in mice.
pubmed:affiliation
College of Pharmacy, Sungkyunkwan University, Jangan-gu, Suwon-si, Gyeonggi-do, Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't