Source:http://linkedlifedata.com/resource/pubmed/id/18187924
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2008-1-23
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| pubmed:abstractText |
We attempted to assess the prophylactic effect of human umbilical cord blood-derived CD34(+) cells in experimental heatstroke. Anesthetized rats, 1 day before heat stress, were divided into 2 major groups and given CD34(-) cells (defined by 1 x 10(6) human cord blood lymphocytes and monocytes that contained <0.2% CD34(+) cells) or CD34(+) cells (defined by 1 x 10(6) human cord blood lymphocytes and monocytes that contained >95% CD34(+) cells). They were exposed to ambient temperature of 43 degrees C for 70 min to induce heatstroke. When the CD34(-) cells-treated or untreated rats underwent heat stress, their survival time values were found to be 20-24 min. Pretreatment with CD34(+) cells significantly increased survival time (123-351 min). As compared with normothermic controls, all CD34(-) cells-treated heatstroke animals displayed hypotension, hepatic and renal failure, hypercoagulable state, activated inflammation, and cerebral ischemia and injury. However, these heatstroke reactions all were significantly suppressed by CD34(+) cells pretreatment. In addition, the levels of interleukin-10 in plasma and glial cell line-derived neurotrophic factors in brain were all significantly increased after CD34(+) cell administration during heatstroke. Our data indicate that human umbilical cord-derived CD34(+) cells can be used as a prophylactic agent for experimental heatstroke.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD34,
http://linkedlifedata.com/resource/pubmed/chemical/Glial Cell Line-Derived...,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrates,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrites,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
1347-8613
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
106
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
46-55
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| pubmed:meshHeading |
pubmed-meshheading:18187924-Animals,
pubmed-meshheading:18187924-Antigens, CD34,
pubmed-meshheading:18187924-Basal Ganglia,
pubmed-meshheading:18187924-Cerebrovascular Disorders,
pubmed-meshheading:18187924-Cord Blood Stem Cell Transplantation,
pubmed-meshheading:18187924-Disease Models, Animal,
pubmed-meshheading:18187924-Fetal Blood,
pubmed-meshheading:18187924-Glial Cell Line-Derived Neurotrophic Factor,
pubmed-meshheading:18187924-Heat Stroke,
pubmed-meshheading:18187924-Humans,
pubmed-meshheading:18187924-Interleukin-10,
pubmed-meshheading:18187924-Kidney Diseases,
pubmed-meshheading:18187924-Liver Diseases,
pubmed-meshheading:18187924-Male,
pubmed-meshheading:18187924-Multiple Organ Failure,
pubmed-meshheading:18187924-Nerve Degeneration,
pubmed-meshheading:18187924-Nitrates,
pubmed-meshheading:18187924-Nitrites,
pubmed-meshheading:18187924-Rats,
pubmed-meshheading:18187924-Rats, Sprague-Dawley,
pubmed-meshheading:18187924-Stem Cells,
pubmed-meshheading:18187924-Time Factors,
pubmed-meshheading:18187924-Tumor Necrosis Factor-alpha
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| pubmed:year |
2008
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| pubmed:articleTitle |
Human umbilical cord blood-derived CD34+ cells can be used as a prophylactic agent for experimental heatstroke.
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| pubmed:affiliation |
Department of Hematology and Oncology, Chi Mei Medical Center, Tainan, Taiwan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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