| pubmed-article:18187923 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18187923 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:18187923 | lifeskim:mentions | umls-concept:C0040822 | lld:lifeskim |
| pubmed-article:18187923 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:18187923 | lifeskim:mentions | umls-concept:C0016733 | lld:lifeskim |
| pubmed-article:18187923 | lifeskim:mentions | umls-concept:C0036751 | lld:lifeskim |
| pubmed-article:18187923 | lifeskim:mentions | umls-concept:C0020934 | lld:lifeskim |
| pubmed-article:18187923 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:18187923 | lifeskim:mentions | umls-concept:C0597360 | lld:lifeskim |
| pubmed-article:18187923 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:18187923 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:18187923 | lifeskim:mentions | umls-concept:C0392760 | lld:lifeskim |
| pubmed-article:18187923 | lifeskim:mentions | umls-concept:C0205191 | lld:lifeskim |
| pubmed-article:18187923 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18187923 | pubmed:dateCreated | 2008-1-23 | lld:pubmed |
| pubmed-article:18187923 | pubmed:abstractText | We examined the influence of imipramine, a traditional tricyclic antidepressant, on the binding to serotonin (5-HT)(2) receptors and levels of 5-HT(2A)-receptor mRNA in the frontal cortex of rats treated with adrenocorticotropic hormone (ACTH). Chronic treatment with ACTH significantly increased the binding of [(3)H]-ketanserin to 5-HT(2) receptors and the expression of 5-HT(2A)-receptor mRNA in the frontal cortex. However, it did not alter the concentration of 5-HT or 5-hydroxyindole acetic acid. The effect of chronic ACTH treatment on 5-HT(2) receptor and 5-HT(2A)-receptor mRNA levels was not altered by the chronic administration of imipramine. Also, imipramine did not affect the hyperfunction of 5-HT(2A) receptors caused by chronic ACTH treatment. These findings suggest that chronic treatment with ACTH acts to increase 5-HT(2A)-receptor synthesis through increased gene transcription, without modulating presynaptic serotonergic neurotransmission. | lld:pubmed |
| pubmed-article:18187923 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18187923 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18187923 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18187923 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18187923 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18187923 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18187923 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18187923 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18187923 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18187923 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18187923 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18187923 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18187923 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18187923 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18187923 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18187923 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:18187923 | pubmed:issn | 1347-8613 | lld:pubmed |
| pubmed-article:18187923 | pubmed:author | pubmed-author:SendoToshiaki... | lld:pubmed |
| pubmed-article:18187923 | pubmed:author | pubmed-author:KitamuraYoshi... | lld:pubmed |
| pubmed-article:18187923 | pubmed:author | pubmed-author:GomitaYutakaY | lld:pubmed |
| pubmed-article:18187923 | pubmed:author | pubmed-author:OuchidaMamoru... | lld:pubmed |
| pubmed-article:18187923 | pubmed:author | pubmed-author:ShimizuKenjiK | lld:pubmed |
| pubmed-article:18187923 | pubmed:author | pubmed-author:KawasakiHirom... | lld:pubmed |
| pubmed-article:18187923 | pubmed:author | pubmed-author:ShibataKazuhi... | lld:pubmed |
| pubmed-article:18187923 | pubmed:author | pubmed-author:KitagawaKouhe... | lld:pubmed |
| pubmed-article:18187923 | pubmed:author | pubmed-author:KanzakiHirota... | lld:pubmed |
| pubmed-article:18187923 | pubmed:author | pubmed-author:FujitaniYoshi... | lld:pubmed |
| pubmed-article:18187923 | pubmed:author | pubmed-author:AkiyamaKozueK | lld:pubmed |
| pubmed-article:18187923 | pubmed:author | pubmed-author:KimotoShizueS | lld:pubmed |
| pubmed-article:18187923 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18187923 | pubmed:volume | 106 | lld:pubmed |
| pubmed-article:18187923 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18187923 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18187923 | pubmed:pagination | 100-6 | lld:pubmed |
| pubmed-article:18187923 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:18187923 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18187923 | pubmed:articleTitle | Increased DOI-induced wet-dog shakes in adrenocorticotropic hormone-treated rats are not affected by chronic imipramine treatment: possible involvement of enhanced 5-HT(2A)-receptor expression in the frontal cortex. | lld:pubmed |
| pubmed-article:18187923 | pubmed:affiliation | Department of Pharmaceutical Care and Health Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan. ykita@pheasant.pharm.okayama-u.ac.jp | lld:pubmed |
| pubmed-article:18187923 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18187923 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:29595 | entrezgene:pubmed | pubmed-article:18187923 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:18187923 | lld:entrezgene |
