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rdf:type |
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lifeskim:mentions |
umls-concept:C0016733,
umls-concept:C0020934,
umls-concept:C0034693,
umls-concept:C0036751,
umls-concept:C0040822,
umls-concept:C0087111,
umls-concept:C0205191,
umls-concept:C0205217,
umls-concept:C0392760,
umls-concept:C0597360,
umls-concept:C1314939,
umls-concept:C2349975
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pubmed:issue |
1
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pubmed:dateCreated |
2008-1-23
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pubmed:abstractText |
We examined the influence of imipramine, a traditional tricyclic antidepressant, on the binding to serotonin (5-HT)(2) receptors and levels of 5-HT(2A)-receptor mRNA in the frontal cortex of rats treated with adrenocorticotropic hormone (ACTH). Chronic treatment with ACTH significantly increased the binding of [(3)H]-ketanserin to 5-HT(2) receptors and the expression of 5-HT(2A)-receptor mRNA in the frontal cortex. However, it did not alter the concentration of 5-HT or 5-hydroxyindole acetic acid. The effect of chronic ACTH treatment on 5-HT(2) receptor and 5-HT(2A)-receptor mRNA levels was not altered by the chronic administration of imipramine. Also, imipramine did not affect the hyperfunction of 5-HT(2A) receptors caused by chronic ACTH treatment. These findings suggest that chronic treatment with ACTH acts to increase 5-HT(2A)-receptor synthesis through increased gene transcription, without modulating presynaptic serotonergic neurotransmission.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4-iodo-2,5-dimethoxyphenylisopropyla...,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenocorticotropic Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Amphetamines,
http://linkedlifedata.com/resource/pubmed/chemical/Antidepressive Agents, Tricyclic,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxyindoleacetic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Imipramine,
http://linkedlifedata.com/resource/pubmed/chemical/Ketanserin,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Serotonin, 5-HT2A,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Receptor Agonists
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1347-8613
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pubmed:author |
pubmed-author:AkiyamaKozueK,
pubmed-author:FujitaniYoshikaY,
pubmed-author:GomitaYutakaY,
pubmed-author:KanzakiHirotakaH,
pubmed-author:KawasakiHiromuH,
pubmed-author:KimotoShizueS,
pubmed-author:KitagawaKouheiK,
pubmed-author:KitamuraYoshihisaY,
pubmed-author:OuchidaMamoruM,
pubmed-author:SendoToshiakiT,
pubmed-author:ShibataKazuhikoK,
pubmed-author:ShimizuKenjiK
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pubmed:issnType |
Print
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pubmed:volume |
106
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
100-6
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:18187923-Adrenocorticotropic Hormone,
pubmed-meshheading:18187923-Amphetamines,
pubmed-meshheading:18187923-Animals,
pubmed-meshheading:18187923-Antidepressive Agents, Tricyclic,
pubmed-meshheading:18187923-Binding Sites,
pubmed-meshheading:18187923-Cerebral Cortex,
pubmed-meshheading:18187923-Disease Models, Animal,
pubmed-meshheading:18187923-Hydroxyindoleacetic Acid,
pubmed-meshheading:18187923-Imipramine,
pubmed-meshheading:18187923-Ketanserin,
pubmed-meshheading:18187923-Male,
pubmed-meshheading:18187923-RNA, Messenger,
pubmed-meshheading:18187923-Rats,
pubmed-meshheading:18187923-Rats, Wistar,
pubmed-meshheading:18187923-Receptor, Serotonin, 5-HT2A,
pubmed-meshheading:18187923-Serotonin,
pubmed-meshheading:18187923-Serotonin Antagonists,
pubmed-meshheading:18187923-Serotonin Receptor Agonists,
pubmed-meshheading:18187923-Time Factors,
pubmed-meshheading:18187923-Tremor,
pubmed-meshheading:18187923-Up-Regulation
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pubmed:year |
2008
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pubmed:articleTitle |
Increased DOI-induced wet-dog shakes in adrenocorticotropic hormone-treated rats are not affected by chronic imipramine treatment: possible involvement of enhanced 5-HT(2A)-receptor expression in the frontal cortex.
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pubmed:affiliation |
Department of Pharmaceutical Care and Health Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan. ykita@pheasant.pharm.okayama-u.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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