18187670

Source:http://linkedlifedata.com/resource/pubmed/id/18187670

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0019080, umls-concept:C0026809, umls-concept:C0042971, umls-concept:C0042974, umls-concept:C0596988, umls-concept:C1457887, umls-concept:C1947976
pubmed:issue	3
pubmed:dateCreated	2008-2-25
pubmed:abstractText	von Willebrand Factor (vWF) structure-function relationship has been studied only in vitro. To investigate the physiological importance of particular vWF domains, we have introduced mutations into murine vWF (mvWF) cDNA inhibiting vWF binding to glycoprotein (Gp) Ib, GpIIbIIIa, and to fibrillar collagen.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9505803
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary, http://linkedlifedata.com/resource/pubmed/chemical/von Willebrand Factor
pubmed:status	MEDLINE
pubmed:month	Mar
pubmed:issn	1524-4636
pubmed:author	pubmed-author:AdlerThureT, pubmed-author:ChristopheOlivier DOD, pubmed-author:ChuiV WVW, pubmed-author:DenisCécile VCV, pubmed-author:LentingPeter JPJ, pubmed-author:MarxIsabelleI
pubmed:issnType	Electronic
pubmed:volume	28
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	419-24
pubmed:dateRevised	2009-11-19
pubmed:meshHeading	pubmed-meshheading:18187670-Animals, pubmed-meshheading:18187670-Bleeding Time, pubmed-meshheading:18187670-Blood Coagulation Tests, pubmed-meshheading:18187670-DNA, Complementary, pubmed-meshheading:18187670-Disease Models, Animal, pubmed-meshheading:18187670-Enzyme-Linked Immunosorbent Assay, pubmed-meshheading:18187670-Female, pubmed-meshheading:18187670-Gene Expression Regulation, pubmed-meshheading:18187670-Gene Therapy, pubmed-meshheading:18187670-Gene Transfer Techniques, pubmed-meshheading:18187670-Male, pubmed-meshheading:18187670-Mice, pubmed-meshheading:18187670-Mice, Inbred C57BL, pubmed-meshheading:18187670-Mice, Mutant Strains, pubmed-meshheading:18187670-Reference Values, pubmed-meshheading:18187670-Sensitivity and Specificity, pubmed-meshheading:18187670-von Willebrand Diseases, pubmed-meshheading:18187670-von Willebrand Factor
pubmed:year	2008
pubmed:articleTitle	Correction of bleeding symptoms in von Willebrand factor-deficient mice by liver-expressed von Willebrand factor mutants.
pubmed:affiliation	INSERM U770, 80 rue du Général Leclerc, 94276 Le Kremlin-Bicêtre Cedex, France.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't