Source:http://linkedlifedata.com/resource/pubmed/id/18187660
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
2008-3-25
|
| pubmed:abstractText |
Post-polycythemia vera myelofibrosis (post-PV MF) is a late evolution of PV. In 647 patients with PV, we found that leukocytosis leukocyte count>(15x10(9)/L) at diagnosis is a risk factor for the evolution of post-PV MF. In a series of 68 patients who developed post-PV MF, median survival was 5.7 years. Hemoglobin level less than 100 g/L (10 g/dL) at diagnosis of post-PV MF was an independent risk factor for survival. The course of post-PV MF, however, is a dynamic process that implies a progressive worsening of clinical parameters. Using a multivariate Cox proportional hazard regression with time-dependent covariates, we found that a dynamic score based on hemoglobin level less than 100 g/L (10 g/dL), platelet count less than 100x10(9)/L, and leukocyte count more than 30x10(9)/L is useful to predict survival at any time from diagnosis of post-PV MF. The resulting hazard ratio of the score was 4.2 (95% CI: 2.4-7.7; P<.001), meaning a 4.2-fold worsening of survival for each risk factor acquired during follow up. In conclusion, leukocytosis at diagnosis of PV is a risk factor for evolution in post-PV MF. A dynamic score based on hemoglobin level, and platelet and leukocyte count predicts survival at any time from diagnosis of post-PV MF.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0006-4971
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| pubmed:author |
pubmed-author:ArcainiLucaL,
pubmed-author:BernasconiPaoloP,
pubmed-author:BoveriEmanuelaE,
pubmed-author:CaramellaMariannaM,
pubmed-author:CazzolaMarioM,
pubmed-author:Del CurtoCeciliaC,
pubmed-author:ElenaChiaraC,
pubmed-author:LazzarinoMarioM,
pubmed-author:MorraEnricaE,
pubmed-author:PascuttoCristianaC,
pubmed-author:PassamontiFrancescoF,
pubmed-author:PietraDanielaD,
pubmed-author:RumiElisaE,
pubmed-author:VanelliLauraL
|
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
111
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3383-7
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:18187660-Adult,
pubmed-meshheading:18187660-Aged,
pubmed-meshheading:18187660-Aged, 80 and over,
pubmed-meshheading:18187660-Follow-Up Studies,
pubmed-meshheading:18187660-Hemoglobins,
pubmed-meshheading:18187660-Humans,
pubmed-meshheading:18187660-Leukocyte Count,
pubmed-meshheading:18187660-Leukocytosis,
pubmed-meshheading:18187660-Male,
pubmed-meshheading:18187660-Middle Aged,
pubmed-meshheading:18187660-Models, Biological,
pubmed-meshheading:18187660-Platelet Count,
pubmed-meshheading:18187660-Polycythemia Vera,
pubmed-meshheading:18187660-Predictive Value of Tests,
pubmed-meshheading:18187660-Primary Myelofibrosis,
pubmed-meshheading:18187660-Prognosis,
pubmed-meshheading:18187660-Regression Analysis,
pubmed-meshheading:18187660-Risk Factors,
pubmed-meshheading:18187660-Survival Rate
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
A dynamic prognostic model to predict survival in post-polycythemia vera myelofibrosis.
|
| pubmed:affiliation |
Department of Hematology, Fondazione Istituto di ricovero e cura a carattere scientifico Policlinico San Matteo, University of Pavia, Italy. f.passamonti@smatteo.pv.it
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study
|