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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1992-7-20
|
| pubmed:abstractText |
The effect of thrombospondin, a major glycoprotein in the platelet alpha-granule, on the erythrocyte aggregation rate was investigated. Venous blood was sampled from 8 healthy male volunteers and anticogulated with 1.1 mg/ml EDTA(K2). The erythrocyte aggregation rate of each blood sample was measured with a whole-blood erythrocyte aggregometer before and after incubation with murine monoclonal antibody against human platelet thrombospondin. After 15 min incubation, the erythrocyte aggregation rate exhibited a significant decrease to 0.055 +/- 0.022/s, representing 71.9 +/- 8.7% of the control value (0.075 +/- 0.028/s) (p less than 0.0005). The results obtained suggest that thrombospondin may participate in the control of erythrocyte aggregability in the circulating blood.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0006-355X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
28
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
551-6
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1818743-Antibodies, Monoclonal,
pubmed-meshheading:1818743-Blood Platelets,
pubmed-meshheading:1818743-Erythrocyte Aggregation,
pubmed-meshheading:1818743-Humans,
pubmed-meshheading:1818743-Male,
pubmed-meshheading:1818743-Platelet Membrane Glycoproteins,
pubmed-meshheading:1818743-Rheology,
pubmed-meshheading:1818743-Thrombospondins
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Monoclonal antibody against platelet thrombospondin decreases erythrocyte aggregation rate.
|
| pubmed:affiliation |
Department of Neurology, Keio University School of Medicine, Tokyo, Japan.
|
| pubmed:publicationType |
Journal Article
|